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MilliporeSigma

EHU135151

MISSION® esiRNA

targeting human SMARCA2

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20 μG

$242.00

50 μG

$435.00

$242.00

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

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description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGATGAGTGATCAGTATGGACCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAGTGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCTATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGATATCATGGTGTAAAAAACACACACATACACAAATATTTGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAAAGCTTTTGATGGAAAATATGTGGGTGGATAGTATATTTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTT

Ensembl | human accession no.

ENSG00000080503

NCBI accession no.

NM_003070

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... SMARCA2(6595), SMARCA2(6595)

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EHU134321EHU064391EHU076601
MISSION® esiRNA targeting human SMARCA2

Sigma-Aldrich

EHU135151

MISSION® esiRNA

MISSION® esiRNA targeting human SMARCA1

Sigma-Aldrich

EHU134321

MISSION® esiRNA

MISSION® esiRNA targeting human SMARCC1

Sigma-Aldrich

EHU064391

MISSION® esiRNA

MISSION® esiRNA targeting human SMARCA4

Sigma-Aldrich

EHU076601

MISSION® esiRNA

Ensembl | human accession no.

ENSG00000080503

Ensembl | human accession no.

ENSG00000102038

Ensembl | human accession no.

ENSG00000173473

Ensembl | human accession no.

ENSG00000127616

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Gene Information

human ... SMARCA2(6595), SMARCA2(6595)

Gene Information

human ... SMARCA1(6594), SMARCA1(6594)

Gene Information

human ... SMARCC1(6599), SMARCC1(6599)

Gene Information

human ... SMARCA4(6597), SMARCA4(6597)

esiRNA cDNA target sequence

ATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGATGAGTGATCAGTATGGACCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAGTGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCTATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGATATCATGGTGTAAAAAACACACACATACACAAATATTTGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAAAGCTTTTGATGGAAAATATGTGGGTGGATAGTATATTTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTT

esiRNA cDNA target sequence

AGATGACTCGCTTGCTGGATATTTTGGAAGATTATTGCATGTGGCGTGGTTATGAGTATTGTCGACTGGATGGACAAACCCCGCATGAAGAAAGAGAGGATAAATTCCTAGAAGTGGAATTTCTGGGTCAAAGGGAAGCAATAGAGGCTTTTAATGCTCCTAATAGTAGCAAATTCATCTTTATGCTAAGTACCAGGGCTGGAGGTCTCGGAATTAACCTGGCAAGTGCTGATGTGGTTATACTATATGATTCAGACTGGAACCCACAGGTTGATCTACAAGCTATGGATCGAGCACATCGTATTGGTCAGAAGAAACCAGTACGTGTATTCCGTCTCATCACTGACAACACTGTTGAAGAGAGGATTGTAGAAAGAGCTGAGATAAAACTGAGACTCGATTCAATTGTTATACAACAAGGAAGACTCATTGACCAA

esiRNA cDNA target sequence

CGGATGAAGGTGATAAAGCACAAGATGGAGAAAATGAAAAAAATAGTGAAAAGGAACAGGATAGTGAAGTGAGTGAGGATACCAAATCAGAAGAAAAGGAGACTGAAGAGAACAAAGAACTCACTGATACATGTAAAGAAAGAGAAAGTGATACTGGGAAGAAGAAAGTAGAACATGAAATTTCCGAAGGAAATGTTGCCACAGCCGCAGCAGCTGCTCTTGCCTCAGCGGCTACCAAAGCCAAGCACCTGGCTGCAGTGGAAGAAAGAAAGATCAAGTCCCTGGTAGCTCTCTTGGTTGAGACACAAATGAAGAAACTAGAGATCAAACTTCGACATTTTGAAGAGCTGGAAACTATCATGGACAGAGAGAAAGAAGCTCTAGAACAACAGAGGCAGCAGTTGCTTACTGAACGCCAAAACTTCCACATGGAACAGCTGAAGTATGCTGAATTACGAGCACGACAGCA

esiRNA cDNA target sequence

GTGGACCTGAATGAGGAGGAAACCATTCTCATCATCCGGCGTCTCCACAAAGTGCTGCGGCCCTTCTTGCTCCGACGACTCAAGAAGGAAGTCGAGGCCCAGTTGCCCGAAAAGGTGGAGTACGTCATCAAGTGCGACATGTCTGCGCTGCAGCGAGTGCTCTACCGCCACATGCAGGCCAAGGGCGTGCTGCTGACTGATGGCTCCGAGAAGGACAAGAAGGGCAAAGGCGGCACCAAGACCCTGATGAACACCATCATGCAGCTGCGGAAGATCTGCAACCACCCCTACATGTTCCAGCACATCGAGGAGTCCTTTTCCGAGCACTTGGGGTTCACTGGCGGCATTGTCCAAGGGCTGGACCTGTACCGAGCCTCGGGTAAATTTGAGCTTCTTGATAGAATTCTTCCCAAACTCCGAGCAACCAACCACAAAGTGCTGCTGT

NCBI accession no.

NM_003070

NCBI accession no.

NM_003069

NCBI accession no.

NM_003074

NCBI accession no.

NM_003072

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
HXU
WWU
CWU
QCS
MZT

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Erika Zernickel et al.
Molecular cancer therapeutics, 18(3), 656-666 (2018-11-28)
Targeting of epigenetic regulators as the chromatin remodeler SWI/SNF is proving to be a promising therapeutic strategy for individualized treatment of cancer patients. Here, we tested whether targeting one of the two mutually exclusive subdomains of the SWI/SNF complex BRM/SMARCA2
Tharu M Fernando et al.
Nature communications, 11(1), 5551-5551 (2020-11-05)
Genomic studies performed in cancer patients and tumor-derived cell lines have identified a high frequency of alterations in components of the mammalian switch/sucrose non-fermentable (mSWI/SNF or BAF) chromatin remodeling complex, including its core catalytic subunit, SMARCA4. Cells exhibiting loss of
Qiong Wu et al.
Journal of cellular physiology, 230(11), 2683-2694 (2015-03-27)
The Brahma (BRM) and Brahma-related Gene 1 (BRG1) ATPases are highly conserved homologs that catalyze the chromatin remodeling functions of the multi-subunit human SWI/SNF chromatin remodeling enzymes in a mutually exclusive manner. SWI/SNF enzyme subunits are mutated or missing in

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