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MilliporeSigma

F0504

Folate binding protein from bovine milk

lyophilized powder

Synonym(s):

Folate Protein

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1 MG

$321.00

5 MG

$1,090.00

$321.00

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131098

Key Documents

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Product Name

Folate binding protein from bovine milk, lyophilized powder

biological source

bovine milk

form

lyophilized powder

composition

Protein, 20-40% modified Warburg-Christian

technique(s)

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

capacity

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

storage temp.

−20°C

Quality Level

200

usage

 mg sufficient for ~4,000 assays

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This Item
C8032A7030C6905
Folate binding protein from bovine milk lyophilized powder

Sigma-Aldrich

F0504

Folate binding protein from bovine milk

α-Casein Dephosphorylated from bovine milk lyophilized powder

Sigma-Aldrich

C8032

α-Casein Dephosphorylated from bovine milk

Bovine Serum Albumin heat shock fraction, protease free, fatty acid free, essentially globulin free, pH 7, ≥98%

Sigma-Aldrich

A7030

Bovine Serum Albumin

β-Casein from bovine milk BioUltra, ≥98% (PAGE)

Sigma-Aldrich

C6905

β-Casein from bovine milk

technique(s)

ligand binding assay: suitable, surface plasmon resonance (SPR): suitable

technique(s)

surface plasmon resonance (SPR): suitable

technique(s)

ELISA: suitable, blood typing: suitable, ligand binding assay: suitable

technique(s)

activity assay: suitable

biological source

bovine milk

biological source

bovine milk

biological source

bovine

biological source

bovine milk

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

essentially salt-free, lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

usage

 mg sufficient for ~4,000 assays

usage

-

usage

-

usage

-

Analysis Note

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

Application

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance[1] and in the uptake studies in kidney proximal tubule cells.[2]
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.[3][4][5]

Biochem/physiol Actions

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio.[6][7] It is involved in the transport of folate and improves their bioavailability.[8]

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing buffer salt as sodium citrate

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000387622
0000316185
0000316185
0000387622
051M7670V

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Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
Claire Corot et al.
Magnetic resonance in medicine, 60(6), 1337-1346 (2008-11-26)
The objective of this study was to evaluate the potential of a high-relaxivity macromolecular gadolinium (Gd) chelate to target folate receptors (FRs). P866 is a dimeric high-relaxivity Gd chelate coupled to a folate moiety. Binding affinity, in vivo biodistribution studies
Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein
Jones ML and Nixon PF
The Journal of Nutrition, 132(9), 2690-2694 (2002)
Nikki Parker et al.
Analytical biochemistry, 338(2), 284-293 (2005-03-05)
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety of cancers. The current development of folate-targeted cancer therapies has created the need for quantitating functional FRs in clinical specimens. In this article, we
View All Related Papers

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