MilliporeSigma
All Photos(1)

Documents

F0931

Sigma-Aldrich

Factor Va human

≥1500 units/mg protein

All Photos(1)
MDL number:
MFCD01093755
NACRES:
NA.61

biological source

human

Quality Level

200

form

solution

specific activity

≥1500 units/mg protein

mol wt

168 kDa

technique(s)

ligand binding assay: suitable

UniProt accession no.

P12259

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... F5(2153)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
F0806219365219370
Sigma-Aldrich

Sigma-Aldrich

F0931

Factor Va human

Sigma-Aldrich

Sigma-Aldrich

F0806

Factor IX human

Sigma-Aldrich

Sigma-Aldrich

219365

Coagulation Factor V, Human Plasma

Sigma-Aldrich

Sigma-Aldrich

219370

Coagulation Factor VIIa, Human Plasma

form

solution

form

aqueous glycerol solution

form

liquid

form

liquid

specific activity

≥1500 units/mg protein

specific activity

≥145 units/mg protein

specific activity

≥20 units/mg protein (clotting assay)

specific activity

≥25,000 PEU/mg protein (clotting assay)

mol wt

168 kDa

mol wt

55 kDa

mol wt

-

mol wt

-

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

-

UniProt accession no.

P12259

UniProt accession no.

P00740

UniProt accession no.

-

UniProt accession no.

-

General description

Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.
Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.

Biochem/physiol Actions

Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.
Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.

Linkage

View this factors role in the Coagulation Cascade

Unit Definition

One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.

Physical form

Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Less Common Congenital Disorders of Hemostasis
Consultative Hemostasis and Thrombosis, 60-78 (2013)
The factor V activation paradox
Orfeo T, et al.
The Journal of Biological Chemistry, 279(19), 19580-19591 (2004)
Eliza A Ruben et al.
Blood, 139(24), 3463-3473 (2022-04-16)
The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca2+ and phospholipids, activates the zymogen prothrombin to the protease thrombin. The reaction
Sandro B Rizoli et al.
The Journal of trauma, 71(5 Suppl 1), S427-S434 (2011-12-17)
Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma transfusion to bleeding trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CFs). This strategy
Eliza A Ruben et al.
Blood, 137(22), 3137-3144 (2021-03-09)
Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates prothrombin in the penultimate step of the coagulation cascade. We solved the cryogenic electron microscopy (cryo-EM) structures of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service