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F3261

Sigma-Aldrich

[Glu1]-Fibrinopeptide B human

≥90% (HPLC)

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Synonym(s):
Fibrinopeptide B
Empirical Formula (Hill Notation):
C66H95N19O26
CAS Number:
Molecular Weight:
1570.57
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

human

Quality Level

Assay

≥90% (HPLC)

form

powder

technique(s)

LC/MS: suitable
electrophoresis: suitable

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)/t32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1

InChI key

KPBJTGOVJLITON-OECXYHNASA-N

Gene Information

human ... FGB(2244)

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1 of 4

This Item
F3254F3879SAB1306505
Fibrinopeptide A human ≥96% (HPLC)

Sigma-Aldrich

F3254

Fibrinopeptide A human

assay

≥90% (HPLC)

assay

≥96% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

powder

form

buffered aqueous solution

technique(s)

LC/MS: suitable, electrophoresis: suitable

technique(s)

ELISA: suitable, mass spectrometry (MS): suitable

technique(s)

ELISA: suitable

technique(s)

flow cytometry: 1:10-1:50, immunohistochemistry: 1:50-1:100, western blot: 1:1000

UniProt accession no.

P02675

UniProt accession no.

P02671

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02675

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Amino Acid Sequence

Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

General description

Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.

Application

[Glu1]-Fibrinopeptide B human has been used:
  • during LC-MS to avoid cross-contamination and to analyze the performance of mass spectrometer and LC-instrument
  • for two-point calibration during 2D (dimensional) gel electrophoresis and protein identification by mass spectrometry of histidine (his)-Pup (prokaryotic ubiquitin-like protein) isolated from Mycobacterium smegmatis
  • for two-point calibration during one-dimensional gel electrophoresis and tandem mass spectrometry (MS) for the characterization of soluble protein sample obtained from the salivary gland homogenates of Cimex lectularius
  • as a standard for the correction of mass drift in data obtained from MS and MS/MS performed on peptides obtained from trypsin-digestion of protein disulfide isomerase (PDI)

Biochem/physiol Actions

Fibrin formation is an essential part in wound healing and inflammation. Fibrinopeptide B (FPB) can also cause chemotactic migration of neutrophils, without the simultaneous release of lysosome enzymes. It is produced during the coagulation of fibrinogen, which is essential for physiological homeostasis. It is involved in various disorders such as thrombosis and disseminated intravascular coagulation.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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