The C-terminus of tissue factor pathway inhibitor α is required for its interaction with factors V and Va.
M Ndonwi et al.
Journal of thrombosis and haemostasis : JTH, 10(9), 1944-1946 (2012-06-29)
Maria Cristina Bravo et al.
BMC systems biology, 6, 45-45 (2012-05-23)
Because understanding of the inventory, connectivity and dynamics of the components characterizing the process of coagulation is relatively mature, it has become an attractive target for physiochemical modeling. Such models can potentially improve the design of therapeutics. The prothrombinase complex...
Daisuke Nakayama et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 65(Pt 12), 1306-1308 (2010-01-08)
Russell's viper venom blood coagulation factor V activator (RVV-V) is a thrombin-like serine proteinase that specifically activates factor V by cleaving a single peptide bond between Arg1545 and Ser1546. Activated factor V combines with activated factor X produced by the...
Kenneth Segers et al.
The Journal of biological chemistry, 282(47), 33915-33924 (2007-09-20)
Human blood coagulation Factor V (FV) is a plasma protein with little procoagulant activity. Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of...
Snake venom proteases that activate blood-coagulation factor V.
W Kisiel et al.
Methods in enzymology, 80 Pt C, 275-285 (1981-01-01)