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MilliporeSigma

F3388

Ferric citrate

BioReagent, suitable for cell culture

Synonym(s):

Iron(III) citrate, Iron(III) citrate hydrate

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250 G

$85.90

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$291.00

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About This Item

Empirical Formula (Hill Notation):
C6H5FeO7
CAS Number:
3522-50-7
Molecular Weight:
244.94
NACRES:
NA.75
PubChem Substance ID:
24894843
UNSPSC Code:
12352205
EC Number:
222-536-6
MDL number:
MFCD00013098

Key Documents

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InChI key

NPFOYSMITVOQOS-UHFFFAOYSA-K

InChI

1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

SMILES string

OC12CC(=O)O[Fe](OC(=O)C1)OC2=O

biological source

synthetic (organic)

product line

BioReagent

technique(s)

cell culture | mammalian: suitable

solubility

hot water: 0.01 g/mL, clear, orange-yellow

shipped in

ambient

storage temp.

room temp

Quality Level

300

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This Item
F6129E6760EDFS
Ferric citrate BioReagent, suitable for cell culture

Sigma-Aldrich

F3388

Ferric citrate

Iron(III) citrate technical grade

Sigma-Aldrich

F6129

Iron(III) citrate

Ethylenediaminetetraacetic acid ferric sodium salt suitable for plant cell culture, BioReagent, crystalline

Sigma-Aldrich

E6760

Ethylenediaminetetraacetic acid ferric sodium salt

Ethylenediaminetetraacetic acid iron(III) sodium salt powder

Sigma-Aldrich

EDFS

Ethylenediaminetetraacetic acid iron(III) sodium salt

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | plant: suitable

technique(s)

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

synthetic (organic)

shipped in

ambient

shipped in

-

shipped in

-

shipped in

-

solubility

hot water: 0.01 g/mL, clear, orange-yellow

solubility

-

solubility

-

solubility

water: 50 mg/mL, clear to slightly hazy, yellow to brown

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

room temp

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

300

Application

Ferric citrate provides a source of iron used in cell culture applications. It provides iron in a less toxic form than free iron salts. Ferric citrate has been used as medium supplement in human osteosarcoma cell (U2OS) culture,[1] human embryonic kidney (HEK293) cells[2] and adult primary cardiomyocytes.[3]

Biochem/physiol Actions

Ferric citrate is used as a component of protein-free medium. It is used as a substitute for transferrin in mouse hybridomas culture. Ferric citrate enhances IgM production.[4] It indirectly stimulates the mitogen-activated protein kinase (MAPK) by favoring high amphiregulin oncoprotein levels in colon cancer.[5]  Ferric citrate is effective in binding to phosphate in patients with dialysis-dependent chronic kidney disease.[6]

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000531610
0000531610
0000514685
0000514685
0000502617

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Development of a protein-free medium with iron salts replacing transferrin for a human-human hybridoma
Nagira K, et al.
Bioscience, Biotechnology, and Biochemistry, 59(4), 743-745 (1995)
Nonantibiotic effects of fluoroquinolones in mammalian cells
Badal S, et al.
The Journal of Biological Chemistry, 290(36), 22287-22297 (2015)
Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells
Scheers NM, et al.
Oncotarget, 9(24), 17066-17066 (2018)
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
Lakhal-Littleton S, et al.
eLife, 5, e19804-e19804 (2016)
Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease
Chertow GM, et al.
PLoS ONE, 12(11), e0188712-e0188712 (2017)
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