4-Fluoro-3-nitrobenzoic acid


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123-126 °C (lit.)

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J C Wijkmans et al.
Molecular diversity, 3(2), 117-120 (1997-01-01)
4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be...
Wen-Bing Yeh et al.
Combinatorial chemistry & high throughput screening, 7(3), 251-255 (2004-05-12)
Liquid phasel synthesis of biheterocyclic benzimidazoles by controlled microwave irradiation was investigated. Polymer immobilized o-phenylenediamines was synthesized under microwave irradiation. The resulting PEG bound diamines was N-acylated with 4-fluoro-3-nitrobenzoic acid selectively in primary aromatic amino moiety. Nucleophilic aromatic substitution of...
D L Ladd et al.
Analytical biochemistry, 210(2), 258-261 (1993-05-01)
We have developed a new class of reagents (2) for the covalent attachment of polyethylene glycol to proteins. These reagents (2) are the monomethoxypolyethylene glycol esters of 4-fluoro-3-nitrobenzoic acid. The reaction of 2 with lysine epsilon-amino groups produces a chromophore...

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