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Feline Chondrocytes, CnC, are derived from normal feline articular cartilage where they produce and maintain the extracellular matrix of cartilage. Following monolayer culturing, FC can be grown in alginate microspheres to study chondrocyte proliferation and metabolism in a three-dimensional in vitro system. Alginate microspheres provide more physiological conditions for the chondrocytes that allow them to sustain normal proteoglycans production and retention. Because of the prevalence of degenerative joint disease (DJD) in geriatric cats, FC can be a useful tool for veterinary practice.
production and maintenance of extracellular matrix, cartilage, collagen, differentiation and de-differentiation, signal transduction, apoptosis, differentiation, drug screening, gene expression, cytokine production, agarose assays, chondrocyte adhesion to medical implants, scaffolds for cartilage regeneration