Unfortunately, the long term stability at -20°C and effect of freeze/thaw cycles have not been evaluated.
F6886
Forskolin
from Coleus forskohlii, ≥98% (HPLC), powder, positive ionotropic agent
Synonym(s):
7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin
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10 MG
$292.00
25 MG
$652.00
50 MG
$1,120.00
About This Item
Empirical Formula (Hill Notation):
C22H34O7
CAS Number:
Molecular Weight:
410.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
266-410-9
MDL number:
Beilstein/REAXYS Number:
1692716
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Product Name
Forskolin, from Coleus forskohlii, ≥98% (HPLC), powder
InChI key
OHCQJHSOBUTRHG-KGGHGJDLSA-N
InChI
1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
SMILES string
CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C
biological source
Coleus forskohlii
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
ethanol: soluble 50 mg/mL
Quality Level
Gene Information
human ... OPRK1(4986), SLC2A10(81031), TNF(7124)
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Related Categories
1 of 4
This Item | F3917 | PHL89664 | 93049 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98.0% (HPLC) | assay ≥95.0% (HPLC) |
| form powder | form powder | form crystals | form - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 100 |
| solubility ethanol: soluble 50 mg/mL | solubility ethanol: soluble | solubility - | solubility - |
| color white to off-white | color white to off-white | color - | color - |
| biological source Coleus forskohlii | biological source Coleus forskohlii | biological source - | biological source - |
General description
Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity.[1] Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use.[2] Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release.[3] Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).[4]
Several studies indicate that forskolin is linked to increased lipolysis, potentially leading to increased fat and weight reduction within the body. The supplementation of forskolin is believed to potentially improve fat loss without losing muscle mass.[5]
Application
Forskolin has been used:
- for inducing mRNA expression in primary hepatocytes.[6]
- as a defatting drug in primary human hepatocytes.[7]
- as a medium supplement to induce differentiation of adipose-derived stem cells (ASCs).[8]
- in the activation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.[9]
- to promote the differentiation of human induced pluripotent stem cells (hiPSCs) into endothelial cells.[10]
- to stimulate cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride ion secretion in differentiated airway epithelial cells derived from individuals with and without cystic fibrosis (CF).[11]
Biochem/physiol Actions
Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Forskolin is soluble in organic solvents such as ethanol, chloroform, and DMSO.
Forskolin solutions at 5 mg/mL in either ethanol or DMSO are stable for at least 6 months at room temperature per HPLC analysis.
This product is to be stored in room temperature . Store the product tightly closed under dry condition.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Use of a high-throughput phenotypic screening strategy to identify amplifiers, a novel pharmacological class of small molecules that exhibit functional synergy with potentiators and correctors
Giuliano KA, et al.
SLAS discovery, 23(2), 111-121 (2018)
Functional polarization of human hepatoma HepaRG cells in response to forskolin
Mayati A, et al.
Scientific Reports, 8(1), 16115-16115 (2018)
Establishment of pharmacokinetic parameters for the herbal drug containing forskolin
Sangeetha S, et al.
Journal of Pharmacy Research, 4(7), 2303-2306 (2011)
Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women
Henderson S, et al.
Journal of the International Society of Sports Nutrition, 2, 1-9 (2005)
Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics
Martinovich KM, et al.
Scientific Reports, 7(1), 17971-17971 (2017)
Articles
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Protocols
A rapid in vitro assay for CFTR function, the forskolin-induced swelling protocol uses human colon organoids, which can be derived from cystic fibrosis patient tissue.
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Can the reconstituted product be stored at -20°C for long-term storage?
1 answer-
Helpful?
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What are the solution stability and storage requirements for this product?
1 answer-
Forskolin solutions at 5 mg/mL in either ethanol or DMSO were found to be stable for at least 6 months at room temperature, as per HPLC analysis
Helpful?
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Can you provide the storage condition after dissolving in the ethanol
1 answer-
Forskolin solutions at 5 mg/mL in either ethanol or DMSO were stable for at least 6 months at room temperature per HPLC analysis.
Helpful?
-
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Any storage guidelines?
1 answer-
This product is to be stored in room temperature . Store the product tightly closed under dry condition.
Helpful?
-
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