F7301

Sigma-Aldrich

Fibroblast Growth Factor-18 human

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):
FGF-18
EC Number:
MDL number:
NACRES:
NA.32
Pricing and availability is not currently available.

Quality Level

biological source

human

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤0.5 ng/mL

mol wt

predicted mol wt 21.2 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... FGF18(8817)

General description

FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.

Biochem/physiol Actions

FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.
FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.

Analysis Note

The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

The crystal structure of fibroblast growth factor 18 (FGF18).
Alan Brown et al.
Protein & cell, 5(5), 343-347 (2014-03-29)
Wei Wei et al.
The Journal of clinical investigation, 123(10), 4435-4448 (2013-09-11)
High-throughput genomic technologies have identified biomarkers and potential therapeutic targets for ovarian cancer. Comprehensive functional validation studies of the biological and clinical implications of these biomarkers are needed to advance them toward clinical use. Amplification of chromosomal region 5q31-5q35.3 has...
Yoshifumi Mori et al.
The Journal of biological chemistry, 289(14), 10192-10200 (2014-03-01)
To identify genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initially compared four types of chondrocytes: articular (AA) versus growth plate (AG) cartilage chondrocytes in adult rats, and superficial layer (IS) versus deep layer...
Articles
Fibroblast growth factors in cell culture and various growth factors for your research
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