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F7932

Famciclovir

≥98% (HPLC)

Synonym(s):

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester, BRL 42810

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$100.00

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About This Item

Empirical Formula (Hill Notation):
C14H19N5O4
CAS Number:
104227-87-4
Molecular Weight:
321.33
NACRES:
NA.77
PubChem Substance ID:
329799767
UNSPSC Code:
12352200
MDL number:
MFCD00866964
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

Famciclovir, ≥98% (HPLC)

InChI

1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)

SMILES string

CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O

InChI key

GGXKWVWZWMLJEH-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: ≥10 mg/mL

originator

Novartis

storage temp.

2-8°C

Quality Level

100

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Show Differences

1 of 4

This Item
1269152PHR16961269174
Famciclovir ≥98% (HPLC)

Sigma-Aldrich

F7932

Famciclovir

Famciclovir United States Pharmacopeia (USP) Reference Standard

USP

1269152

Famciclovir

Famciclovir Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1696

Famciclovir

USP

USP

1269174

Famciclovir Related Compound A

form

solid

form

-

form

-

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: ≥10 mg/mL

solubility

-

solubility

-

solubility

-

Application

Famciclovir is used in herpes virus infections and hepatitis B drug development research. It may be used as a reference compound. Famciclovir may be used to study the factors that control its conversion into penciclovir and other metabolites.[1][2]

Biochem/physiol Actions

Famciclovir is an Antiviral; Guanine analog used to treat herpesvirus infections.
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000417553
0000417553
0000225374
0000225374
080M4708V

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Anthony Cunningham et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 53(1), 6-11 (2011-09-06)
Herpes labialis is a common skin infective condition, worldwide, which is primarily caused by HSV-1. Recurrent episodes of herpes labialis, also known as cold sores, can be frequent, painful, long-lasting and disfiguring for infected patients. At present, there are two
Generic acyclovir vs. famciclovir and valacyclovir.
C Grose et al.
The Pediatric infectious disease journal, 16(9), 838-841 (1997-11-05)
Joshua T Schiffer et al.
The Journal of antimicrobial chemotherapy, 66(11), 2593-2600 (2011-08-26)
The presence of herpes simplex virus-2 (HSV-2) shedding episodes correlates with transmission to sexual partners and neonates, and some episodes correlate with disease manifestations. HSV-2-targeted guanosine analogues are effective when given on a prophylactic basis, but do not completely eliminate
Samira Mubareka et al.
Expert opinion on drug safety, 9(4), 643-658 (2010-05-01)
Famciclovir is the prodrug of penciclovir, a guanosine analogue that inhibits viruses of the alpha sub-family of the Herpesviridae, as well as hepatitis B virus. It is indicated for management of mucocutaneous herpes simplex virus disease and acute herpes zoster
Donald C Vinh et al.
Expert opinion on pharmacotherapy, 7(16), 2271-2286 (2006-10-25)
Herpes simplex virus is one of the most common causes of genital ulcer disease worldwide. Herpes simplex virus-2 is the more common cause of genital herpes, a chronic infection that is characterised by periodic reactivation, with the capacity to produce
View All Related Papers

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