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F8423

Sigma-Aldrich

Fluorouracil

meets USP testing specifications

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Synonym(s):
5-Fluorouracil, 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
Empirical Formula (Hill Notation):
C4H3FN2O2
CAS Number:
Molecular Weight:
130.08
Beilstein:
127172
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.71

Agency

USP/NF
meets USP testing specifications

mp

282-286 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

Gene Information

human ... TYMS(7298)

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1 of 4

This Item
F6627BP9958.18505
Fluorouracil meets USP testing specifications

Sigma-Aldrich

F8423

Fluorouracil

5-Fluorouracil ≥99% (HPLC), powder

Sigma-Aldrich

F6627

5-Fluorouracil

Fluorouracil British Pharmacopoeia (BP) Reference Standard

BP995

Fluorouracil

5-Fluorouracil for synthesis

Sigma-Aldrich

8.18505

5-Fluorouracil

agency

USP/NF

agency

-

agency

-

agency

-

mp

282-286 °C (dec.) (lit.)

mp

282-286 °C (dec.) (lit.)

mp

282-286 °C (dec.) (lit.)

mp

282-283 °C (decomposition)

application(s)

pharmaceutical (small molecule)

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

pharmaceutical

application(s)

-

Gene Information

human ... TYMS(7298)

Gene Information

human ... TYMS(7298)

Gene Information

human ... TYMS(7298)

Gene Information

-

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


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Aurélien Montagu et al.
European journal of medicinal chemistry, 46(2), 778-786 (2011-01-15)
The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)-nucleoside derivatives is described. The key steps of this synthesis are regioselective Huisgen's 1,3-dipolar cycloaddition, using either copper-catalyzed azide-alkyne cycloaddition (CuAAC) or ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) under microwave activation.
Julia K J Ahlskog et al.
Bioorganic & medicinal chemistry letters, 19(16), 4851-4856 (2009-07-21)
We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of
Zhiyang Chen et al.
Nature communications, 6, 6808-6808 (2015-04-17)
Wild-type p53-induced phosphatase 1 (Wip1) negatively regulates several tumour suppressor and DNA damage response pathways. However, the impact of Wip1 on haematopoietic stem cell (HSC) homeostasis and aging remains unknown. Here we show that Wip1 is highly expressed in HSCs
Umashankar Das et al.
Journal of medicinal chemistry, 54(9), 3445-3449 (2011-04-01)
Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a-e) display potent cytotoxicity and a preferential lethality toward various neoplasms compared to some normal cells. The corresponding sulfonic acid analogues 5a-e and an isostere 4 demonstrated substantially lower activity. The leads 3d and 3e possess very high
Umashankar Das et al.
European journal of medicinal chemistry, 42(1), 71-80 (2006-09-26)
The 3,5-bis(arylidene)-4-piperidones 1 contain the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore which is considered to interact at a complementary binding site in susceptible neoplasms. The hypothesis was formulated that the presence of an acyl group attached to the piperidyl nitrogen atom in series 1

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