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Folic acid

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Pterylmonoglutamic acid, PteGlu, Vitamin M, Pteroyl-L-glutamic acid
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

biological source


product line






mol wt

Mw 441.40 g/mol


cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable


dark yellow


1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange

storage temp.

room temp

SMILES string




InChI key


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General description

Folic acid (FA)/pterylmonoglutamic acid helps to block neural tube defects (NTDs).


Folic acid has been used:
  • to study the role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
  • in cells and treatments
  • in perforin gene targeting using the CRISPR/Cas gene editing approach


5, 25 g in glass bottle

Biochem/physiol Actions

A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8758.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

Storage Class Code

11 - Combustible Solids



Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Product Information Sheet

More documents

Quotes and Ordering

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of folic acid (Product No. F8758)?

    Product No. F8758 is soluble in 1 M NaOH (50 mg/mL). The free acid is only slightly soluble in water (0.01 mg/mL at 0 °C), and is insoluble in aqueous solutions below pH 5. It is soluble in sodium bicarbonate or sodium hydroxide solutions.

  6. What is the stability of folic acid (Product No. F8758) once in solution?  

    This product is photolabile and is inactivated by UV light. Alkaline solutions are reasonably stable in the dark, but heating will destroy both alkaline and acidic solutions.

  7. Is Product No. F8758, Folic Acid, tested for endotoxins?  

    No, Product No. F8758 has not been tested for endotoxins. This product has, however, been tested for use in mammalian cell culture and insect cell culture.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Folic acid handling by the human gut: implications for food fortification and supplementation
Patanwala I, et al.
American Journal of Clinical Nutrition, 100(2), 593-599 (2014)
Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study
Li Z, et al.
International Journal of Epidemiology, 43(4), 1132-1139 (2014)
Reduced expression of galectin-9 contributes to a poor outcome in colon cancer by inhibiting NK cell chemotaxis partially through the Rho/ROCK1 signaling pathway
Wang Y, et al.
PloS one, 11(3), e0152599-e0152599 (2016)
Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2
Sevim H, et al.
Stem Cell Research & Therapy, 9(1), 198-198 (2018)
The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
Ducommun P, et al.
Cytotechnology, 37(2), 65-73 (2001)


Folic Acid and Tetrahydrofolates in Cell Culture

Importance and uses of folic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures. Folic acid and its reduced derivative(s), such as folinic acid, are an essential water soluble vitamins added to virtually all cell culture media.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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