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F8932

Fatostatin hydrobromide

≥98% (HPLC), powder

Synonym(s):

25B11 hydrobromide, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide, Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide

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$111.00

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$606.00

$111.00

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About This Item

Empirical Formula (Hill Notation):
C18H18N2S·HBr
CAS Number:
298197-04-3
Molecular Weight:
375.33
MDL number:
MFCD00760867
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Product Name

Fatostatin hydrobromide, ≥98% (HPLC), powder

SMILES string

[s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br

InChI

1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H

InChI key

RJCFNQZVFUMORB-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow to yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

Quality Level

100

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This Item
341329PZ0298P4236
Fatostatin hydrobromide ≥98% (HPLC), powder

Sigma-Aldrich

F8932

Fatostatin hydrobromide

Fatostatin A cell-permeable diarylthiazole compound that prevents the cellular activation of the SREBP-1/2 precursors to the active nuclear forms by blocking SREBPs-SCAP ER to Golgi translocation.

Sigma-Aldrich

341329

Fatostatin

PF-03084014 hydrobromide ≥98% (HPLC)

Sigma-Aldrich

PZ0298

PF-03084014 hydrobromide

Cyclic Pifithrin-α hydrobromide ≥98% (HPLC)

Sigma-Aldrich

P4236

Cyclic Pifithrin-α hydrobromide

form

powder

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

−20°C

storage condition

desiccated

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

desiccated

storage condition

desiccated

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 10 mg/mL

solubility

H2O: 1 mg/mL, clear

solubility

DMSO: 20 mg/mL

Application

Fatostatin hydrobromide has been used:
  • to study its anti-cancer activity and effects on mitotic microtubule spindle[1]
  • to study its effects on stomatal development[2]
  • to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)[3]

Biochem/physiol Actions

Fatostatin hydrobromide is an SREBP inhibitor.
Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).

General description

Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor[4] and antimitotic properties.[1]

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000159855
0000131435
0000084101
0000115840

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Yumiko Sakai et al.
Development (Cambridge, England), 144(3), 499-506 (2017-01-15)
Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it
Chih-Ming Huang et al.
Cells, 9(1) (2019-12-22)
: Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to investigate the therapeutic
Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling
Li X, et al.
Molecular Cancer Therapeutics, 13(4), 855-866 (2014)
Inhibition of cell polarity establishment in stomatal asymmetric cell division using the chemical compound bubblin
Sakai Y, et al.
Development, dev-145458 (2017)
Jessica E Rexach et al.
Cell reports, 33(7), 108398-108398 (2020-11-19)
To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD, and PSP. We uncover a complex temporal trajectory of
View All Related Papers

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