G1001

D-Glutamic acid

≥99% (TLC)

• Synonym(s): (R)-2-Aminoglutaric acid, (R)-2-Aminopentanedioic acid, D-Glu, R-(−)-1-Aminopropane-1,3-dicarboxylic acid
• Linear Formula: HO₂CCH₂CH₂CH(NH₂)CO₂H
• CAS Number: 6893-26-1
• Molecular Weight: 147.13
• Beilstein: 1723800
• EC Number: 230-000-8
• MDL number: MFCD00063112
• PubChem Substance ID: 24895031
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥99% (TLC)
• form: powder
• technique(s): ligand binding assay: suitable
• color: white to off-white
• mp: 200-202 °C (subl.) (lit.)
• SMILES string: N[C@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
• InChI key: WHUUTDBJXJRKMK-GSVOUGTGSA-N
• Gene Information: human ... CCR2(1231)

Description

General description

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Application

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.

Biochem/physiol Actions

Unnatural isomer of glutamic acid.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves