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G1397

Sigma-Aldrich

Gentamicin

Gentamicin solution
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liquid, non-animal origin, suitable for cell culture, BioReagent

Synonym(s):

Gentamicin

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10 ML
$83.90
100 ML
$725.00

About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352207
eCl@ss:
42020823
PubChem Substance ID:
NACRES:
NA.76

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Product Name

Gentamicin solution, 50 mg/mL in deionized water, liquid, 0.1 μm filtered, BioReagent, suitable for cell culture

biological source

microbial

Quality Level

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

potency

50-60 mg per mL

concentration

50 mg/mL in deionized water

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless to light yellow

density

1.000 g/cm3

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

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Show Differences

1 of 4

This Item
G1522G1264G3632
antibiotic activity spectrum

Gram-negative bacteria, mycoplasma, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | hybridoma: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

product line

BioReagent

product line

BioReagent

product line

BioReagent

product line

-

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

form

liquid

form

liquid

form

powder

form

powder

biological source

microbial

biological source

-

biological source

Micromonospora purpurea

biological source

Micromonospora purpurea

General description

Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis.[1] Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.[2]

Application

Gentamicin solution has been used as an antibiotic component in eukaryotic cell culture[3][4][5][6][7][8] and bacterial culture.[9][10][11]
Gentamicin sulfate is a broad-spectrum antibiotic used as a selection agent (gentamicin-resistance gene) in molecular biology and cell culture applications.[12][13] This product is formulated to contain 50 mg/mL Gentamicin in deionized water and is recommended for use in eukaryotic cell culture at a volume of 1 milliliter per liter.
Gentamicin sulfate solution has been used as a component of different types of culture media.[14]

Biochem/physiol Actions

Gentamicin is recommended for treating sepsis during emergency treatment.[15] It is an alternate to ceftriaxone for treating genital infection.[16]
Mode of Action: Gentamicin inhibits protein synthesis by binding to the 30S subunit of the ribosome.

Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Components

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.

Caution

The product is stable at 37° for 5 days and is stored at 2-8°C.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Questions

  1. Hi, I have a query. Is G-1397 Gentamicin sulfate solution? Please provide the information of the powder form (CAS no) of this Gentamicin solution. We would like to order powder form. Thank you so much.

    1 answer
    1. The powder form of Gentamicin for use in Cell Culture is product G1264. See the link below to access this product page:
      https://www.sigmaaldrich.com/product/sigma/g1264

      Additional Gentamicin product options may be reviewed at the link below:
      https://www.sigmaaldrich.com/search/1405-41-0?focus=products&page=1&perpage=30&sort=relevance&term=1405-41-0&type=cas_number

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Reviews

1 of 2 reviewers took part in a promotion

Active Filters

  1. Portland, Oregon
    • Review 1
    • Vote 1
    5 out of 5 stars.

    Best Drug

    good to grow cells in culture, no toxicity in culture

    Helpful?

  2. 1 Ratings-Only Review

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