G1501

L-Glutamic acid potassium salt monohydrate

≥99% (HPLC), powder

• Synonym(s): MPG, Monopotassium glutamate, Potassium 2-amino-5-hydroxy-5-oxopentanoate, (S)-2-Aminopentanedioic acid, L-α-Aminoglutaric acid potassium salt, L-2-Aminopentanedioic acid potassium salt, Glu, Potassium L-glutamate
• Empirical Formula (Hill Notation): C₅H₈KNO₄ · H₂O
• CAS Number: 6382-01-0
• Molecular Weight: 203.23
• MDL number: MFCD00150343
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895063
• NACRES: NA.32
• Beilstein/REAXYS Number: 3637377

Properties

• Quality Level: 300
• assay: ≥99% (HPLC)
• form: powder
• color: white
• SMILES string: O.[K+].N[C@@H](CCC([O-])=O)C(O)=O
• InChI: 1S/C5H9NO4.K.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1
• InChI key: XIBUKSQTWSKJMQ-QTNFYWBSSA-M
• Gene Information: human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907) ; mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168) ; rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Description

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.[1] Potassium -glutamate is also used as a component of MEM non-essential amino acids solution in cell culture.

Application

L-Glutamic acid potassium salt monohydrate has been used-

• A component of MEM non-essential amino acids solution in cell culture.
• For the purification of tubulins from bovine brain.
• In stock solution for the preparation of quenching buffer during the formationof dual-color polarity-marked fluorescent microtubule seeds.[2]
• The preparation of cell free extracts devoid of RF2 (release factor 2) from Escherichia coli strains.[3]
• preparation of stock solutions during culture of Arabidopsis plants.[4]

Biochem/physiol Actions

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease.[1] Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.[5]

Features and Benefits

Our highly purified L-Glutamic acid potassium salt monohydrate will support your purification or preparation neuropathological diseases research needs

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)