G1514

D-(+)-Glucosamine hydrochloride

≥99%, BioReagent, suitable for cell culture

• Synonym(s): 2-Amino-2-deoxy-D-glucose hydrochloride, Chitosamine hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₃NO₅ · HCl
• CAS Number: 66-84-2
• Molecular Weight: 215.63
• Beilstein/REAXYS Number: 4157370
• EC Number: 200-638-1
• MDL number: MFCD00135831
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895066
• NACRES: NA.75

Properties

• biological source: Aspergillus niger; maize fruit
• Quality Level: 200
• product line: BioReagent
• assay: ≥99%
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 190-194 °C (dec.) (lit.)
• solubility: water: 100 mg/mL, clear, colorless
• SMILES string: Cl.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4-,5-,6?;/m1./s1
• InChI key: QKPLRMLTKYXDST-NSEZLWDYSA-N

Description

General description

Glucosamine, an amino sugar is generated form glucose and glutamine[1] and is naturally produced in the body.[2] Glucosamine, a endogenous amino monosaccharide[2] is the major source of glucosamine-6-phosphate and n-acetylglucosamine.[1]

Application

Glucosamine has been used as a standard to examine the concentration of glucosamine in the synovial fluid and its pharmacokinetics in serum.[3]

Biochem/physiol Actions

Glucosamine is preferred as a nutritional supplement for individuals with osteoarthritis.[4] It is used as a building block for the production of proteoglycans and glycosaminoglycans.[2]

Glucosamine, an amino sugar, is the precursor of the hexosamine biosynthetic pathway leading to the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is then used for making glycosaminoglycans, proteoglycans, and glycolipids. D-(+)-Glucosamine inhibits the coaggregation of Candida yeast species with the bacterial strain S. salivarius.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)