G1887

Gly-His-Lys acetate salt

≥97% (TLC)

• Synonym(s): Liver cell growth factor
• Linear Formula: C₁₄H₂₄N₆O₄C₂H₄O₂
• CAS Number: 72957-37-0
• Molecular Weight: 400.43
• MDL number: MFCD00012699
• UNSPSC Code: 51111800
• PubChem Substance ID: 24894913
• NACRES: NA.32

Properties

• SMILES string: CC(O)=O.NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(O)=O
• InChI: 1S/C14H24N6O4.C2H4O2/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;1-2(3)4/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);1H3,(H,3,4)/t10-,11-;/m0./s1
• InChI key: MGNUTAFMLGJBGV-ACMTZBLWSA-N
• assay: ≥97% (TLC)
• composition: Peptide content, ~70%
• storage temp.: −20°C
• Quality Level: 200

Description

General description

Gly-His-Lys is a tripeptide present at ∼200ng/ml in association with α-globulin and albumin, in human blood plasma.[1]

Application

Gly-His-Lys (GHK) has been used for the preparation of post-operative intra-articular injection of GHK-Cu (copper).[2]

Gly-His-Lys acetate salt has been used:

• individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines[3]
• as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies[4]
• as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5[5]

Biochem/physiol Actions

Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells.[3] GHK is also involved in quenching toxic by-products generated by lipid peroxidation.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable