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  • G1918
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G1918

Sigma-Aldrich

Gö 6983

≥97%

Synonym(s):
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Empirical Formula (Hill Notation):
C26H26N4O3
CAS Number:
Molecular Weight:
442.51
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥97%

form

powder

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

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Gö 6983 ≥97%

Sigma-Aldrich

G1918

Gö 6983

Sigma-Aldrich

Sigma-Aldrich

SML3447

GO289

Gossypetin ≥98% (HPLC)

Sigma-Aldrich

SML3464

Gossypetin

Gossypin ≥90% (HPLC)

Sigma-Aldrich

SML0761

Gossypin

assay

≥97%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

form

powder

form

powder

form

powder

form

powder

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).

Biochem/physiol Actions

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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