G2761

Gly-Pro-7-amido-4-methylcoumarin hydrobromide

Name: Gly-Pro-7-amido-4-methylcoumarin hydrobromide
Brand: SIGMA
Price: 500 USD
Availability: InStock

dipeptidylpeptidase IV substrate

Synonym(s):

Gly-Pro-AMC

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G2761-25MG

$500.00

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉N₃O₄ · HBr

CAS Number:

115035-46-6

Molecular Weight:

410.26

MDL number:

MFCD00152092

UNSPSC Code:

12352204

PubChem Substance ID:

24895103

NACRES:

NA.32

Key Documents

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Quality Level

200

assay

≥97% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

Br.CC1=CC(=O)Oc2cc(NC(=O)[C@@H]3CCCN3C(=O)CN)ccc12

InChI

1S/C17H19N3O4.BrH/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18;/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23);1H/t13-;/m0./s1

InChI key

PASXTQMFJRHMLJ-ZOWNYOTGSA-N

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Show Differences

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This Item	T0273	G9137	A3401
Sigma-Aldrich G2761 Gly-Pro-7-amido-4-methylcoumarin hydrobromide	Sigma-Aldrich T0273 N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride	Sigma-Aldrich G9137 Gly-Pro 4-methoxy-β-naphthylamide	Sigma-Aldrich A3401 Ala-Ala-Phe-7-amido-4-methylcoumarin
assay ≥97% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)
solubility water: 50 mg/mL, clear, colorless to light yellow	solubility acetic acid: 10 mg/mL, clear, colorless	solubility ethanol: 50 mg/mL, clear, colorless to faintly yellow	solubility ethanol: 20 mg/mL, clear, colorless to light yellow
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

General description

Substrate for dipeptidylaminopeptidase IV.

Application

Gly-Pro-7-amido-4-methylcoumarin hydrobromide has been used as a substrate for determining the dipeptidylpeptidase IV (DPPIV) activity of the extract of Allophylus cominia Sw.[1]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000446245

0000349705

0000295820

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Fluorescence assay of x-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate.

T Kato et al.

Biochemical medicine, 19(3), 351-359 (1978-06-01)

In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes

Semaan DG, et al.

Journal of Ethnopharmacology, 203, 39-46 (2017)

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion.

Sandy Theysgeur et al.

Molecules (Basel, Switzerland), 26(1) (2021-01-06)

Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related

Standardized Emblica officinalis fruit extract inhibited the activities of α-amylase, α-glucosidase, and dipeptidyl peptidase-4 and displayed antioxidant potential.

Muhammed Majeed et al.

Journal of the science of food and agriculture, 100(2), 509-516 (2019-09-06)

Emblica officinalis, known as amla in Ayurveda, has been used as a folk medicine to treat numerous pathological conditions, including diabetes. However, the novel extract of E. officinalis fruit extract (amla fruit extract, AFE, Saberry®) containing 100 g kg-1 β-glucogallin along with

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