G2879

Glycine hydrochloride

≥99% (HPLC), NMDA receptors regulator, powder

• Synonym(s): Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: H₂NCH₂CO₂H · HCl
• CAS Number: 6000-43-7
• Molecular Weight: 111.53
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895108
• NACRES: NA.32
• EC Number: 227-841-8
• MDL number: MFCD00012872

Properties

• Product Name: Glycine hydrochloride, ≥99% (HPLC)
• SMILES string: Cl.NCC(O)=O
• InChI: 1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
• InChI key: IVLXQGJVBGMLRR-UHFFFAOYSA-N
• assay: ≥99% (HPLC)
• form: powder
• mol wt: 111.53
• storage condition: (Tightly closed Dry)
• concentration: ≤100%
• technique(s): immunohistochemistry: suitable
• mp: 176-180 °C (lit.)
• solubility: water: 0.5 g/mL, clear, colorless
• storage temp.: room temp
• Quality Level: 300

Description

General description

Research area: Neuroscience

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.[1]

Glycine hydrochloride has been used:

• in the preparation of glycine-HCl buffer[2]
• to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies[3]
• to regenerate the sensor to elute the bound C-reactive protein (CRP)[4]

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.[5][6]

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group.[7] Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane.[8] It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices.[7] Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.[7]Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.[9]

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)