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G3295

GW0742

≥98% (HPLC), selective PPARδ agonist, powder

Synonym(s):

4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

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$258.00

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$879.00

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About This Item

Empirical Formula (Hill Notation):
C21H17F4NO3S2
CAS Number:
317318-84-6
Molecular Weight:
471.49
UNSPSC Code:
12352200
PubChem Substance ID:
24895123
NACRES:
NA.77
MDL number:
MFCD07369423

Key Documents

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Product Name

GW0742, ≥98% (HPLC)

mp

134.5-135.5 °C

solubility

DMSO: >5 mg/mL
H2O: insoluble

originator

GlaxoSmithKline

form

powder

color

white

SMILES string

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI key

HWVNEWGKWRGSRK-UHFFFAOYSA-N

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

assay

≥98% (HPLC)

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... PPARA(5465), PPARD(5467), PPARG(5468)

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This Item
SML1491S3944SML2281
GW0742 ≥98% (HPLC)

Sigma-Aldrich

G3295

GW0742

GW501516 ≥98% (HPLC)

Sigma-Aldrich

SML1491

GW501516

SEW2871 ≥98% (HPLC), solid

Sigma-Aldrich

S3944

SEW2871

BAY 60-2770 ≥98% (HPLC)

Sigma-Aldrich

SML2281

BAY 60-2770

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

solubility

DMSO: 2 mg/mL, clear

color

white

color

white to beige

color

white

color

white to beige

Biochem/physiol Actions

GW0742 is a highly selective PPARδ agonist.
GW0742 is a highly selective PPARδ agonist. EC50 = 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000479230
0000364099
0000364099
0000232793
0000232794

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Bruce E Heck et al.
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Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA, and the population is expected to reach 67 million in the United States by 2030. Thus
Amar Bahadur Singh et al.
The Journal of biological chemistry, 292(3), 884-897 (2016-12-04)
Peroxisome proliferator-activated receptor δ (PPARδ) regulates many genes involved in lipid metabolism. Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty
Haruyo Yagi et al.
Stem cell research & therapy, 11(1), 293-293 (2020-07-19)
There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop more effective and less invasive forms of antimicrobial
Koichiro Kawaguchi et al.
FEBS open bio, 6(3), 190-199 (2016-04-06)
Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in
Luka Opitz et al.
Journal of anatomy, 231(6), 970-977 (2017-08-09)
Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions
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