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G5640

Sigma-Aldrich

Globulins Cohn fraction II, III from goat

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Synonym(s):
Vitamin D binding protein
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

goat

Assay

73-90% protein basis (biuret)

form

lyophilized powder

composition

Protein, 73-90% biuret

solubility

H2O: soluble 25 mg/mL

storage temp.

2-8°C

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This Item
G4386G2388G2018
assay

73-90% protein basis (biuret)

assay

≥99% (electrophoresis)

assay

-

assay

≥99% (agarose gel electrophoresis)

form

lyophilized powder

form

powder

form

lyophilized powder

form

powder

solubility

H2O: soluble 25 mg/mL

solubility

0.9% NaCl: soluble 50 mg/mL

solubility

-

solubility

0.9% NaCl: soluble 50 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

General description

Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis.

Application

Globulins were used in Biotin/avidin formulations.

Biochem/physiol Actions

Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease.

Other Notes

Primarily γ-globulins

Physical form

Lyophilized powder containing NaCl

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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