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G5660

Sigma-Aldrich

Lysoganglioside-GM1 from bovine brain

≥95%, lyophilized powder

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CAS Number:
171483-40-2
MDL number:
MFCD00677269

Quality Level

200

Assay

≥95%

form

lyophilized powder

storage temp.

−20°C

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Lysoganglioside-GM1 from bovine brain ≥95%, lyophilized powder

Sigma-Aldrich

G5660

Lysoganglioside-GM1 from bovine brain

Asialoganglioside GM1 from bovine brain ~98%, lyophilized powder

Sigma-Aldrich

G3018

Asialoganglioside GM1 from bovine brain

Disialoganglioside-GD2 from bovine brain ~95%, lyophilized powder, semisynthetic

Sigma-Aldrich

G0776

Disialoganglioside-GD2 from bovine brain

Disialoganglioside GD1a from bovine brain ≥95% (TLC), lyophilized powder

Sigma-Aldrich

G2392

Disialoganglioside GD1a from bovine brain

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Biochem/physiol Actions

Suggested to be a modulator of cell growth and signal transduction. Accumulates in the nervous system of patients with GM1 gangliosidosis. Used for the preparation of GM1 derivatives containing different fatty acids, fluorescent tags, or other residues.

Other Notes

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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T Kobayashi et al.
Journal of neurochemistry, 59(4), 1452-1458 (1992-10-01)
By using a sensitive method, we assayed lysocompounds of gangliosides and asialogangliosides in tissues from four patients with GM2 gangliosidosis (one with Sandhoff disease and three with Tay-Sachs disease) and from three patients with GM1 gangliosidosis [one with infantile type
Tubaro, E., et al.
Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Soc., 248, 175-175 (1993)
A Kharlamov et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(14), 6303-6307 (1994-07-05)
A bilateral photochemically induced thrombotic lesion of rat sensorimotor cortex (approximately 3 mm in diameter and 25 mm3 in volume) is associated with a persistent cognition (learning and memory) deficit, which was evaluated with water maze tasks. The N-dichloroacetylsphingosine derivative
R T Huang et al.
FEBS letters, 281(1-2), 39-42 (1991-04-09)
Fluorescent dansyl derivatives of 3 natural sphingolipids (gangliosides, cerebroside and sphingomyelin) were shown to be readily taken up by culture cells (HeLa-, MDCK- and primary rat brain cells). A part of the incorporated fluorescent sphingolipids remained associated with the cells
Y A Hannun et al.
Science (New York, N.Y.), 235(4789), 670-674 (1987-02-06)
Lysosphingolipids potently and reversibly inhibited protein kinase C activity and binding of phorbol dibutyrate in vitro and in human platelets. As with activation of protein kinase C by phosphatidylserine and sn-1,2-diacylglycerol, inhibition was subject to surface dilution. Accordingly, inhibition in

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