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G6910

Supelco

Ginkgolide B from Ginkgo biloba leaves

≥90% (HPLC)

Synonym(s):

BN-52021

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50 MG
$513.00

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10 MG
$139.00
50 MG
$513.00

About This Item

Empirical Formula (Hill Notation):
C20H24O10
CAS Number:
Molecular Weight:
424.40
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

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Quality Level

assay

≥90% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]36[C@@H](O)C(=O)O[C@H]6O[C@@]4(C(=O)O5)[C@@]12O

InChI

1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1

InChI key

SQOJOAFXDQDRGF-MMQTXUMRSA-N

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General description

Ginkgolide B from Ginkgo biloba leaves is a terpene lactone and one of the main molecular form of ginkgolides, present in Ginkgo biloba leaves. It is widely used to treat peripheral and cerebral circulation disorders.[1]

Application

Ginkgolide B from Ginkgo biloba leaves is used as an analytical reference standard:
  • For the chromatographic separation of the analyte in Ginkgo biloba leaves extract and to study the antimicrobial activity exerted on a variety of Gram-positive and -negative bacteria and yeasts.[2]
  • For the determination of the analyte in Ginkgo biloba L. phytopharmaceuticals using high-performance liquid chromatography technique.[1]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Primary constituent of Ginkgo biloba. Potential anticancer agent and neuroprotective.

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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Antimicrobial investigation of semi-purified fractions of Ginkgo biloba leaves
Mazzanti.G, et al.
Journal of Ethnopharmacology, 71(1-2), 83-88 (2005)
Christoph A Reichel et al.
PloS one, 6(2), e17229-e17229 (2011-03-03)
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear. Using in vivo microscopy on the cremaster muscle of male C57BL/6 mice, aprotinin as well
Yuan Yuan et al.
Journal of chromatographic science, 51(3), 266-272 (2012-08-31)
A sensitive, simple and rapid liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of ginkgolide B (GB) and the prodrug of ginkgolide B (PGB) in rat plasma and brain tissue. Detection was performed on a
Karyn M Maclennan et al.
Progress in neurobiology, 67(3), 235-257 (2002-08-10)
Ginkgo biloba extracts such as EGb-761 have been suggested to have a multitude of beneficial effects on CNS function, from enhancing cognitive function in dementia to facilitating recovery from acute forms of neural damage such as hypoxia/ischemia. Ginkgolide B, one
Peng Lv et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 44(3), 235-240 (2011-08-23)
Cerebral ischemia and reperfusion is one of the leading causes for death and severe disabilities in the world and often lead to irreversible brain damage over later lifespan. The aim of this study was to investigate the evolution of pathological

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