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G7127

Guanosine 5′-diphosphate sodium salt

≥96% (HPLC), synthetic (organic), powder

Guanosine 5′-diphosphate sodium salt

Synonym(s):

GDP

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G7127-10MG

$83.20

G7127-25MG

$93.50

G7127-100MG

$198.00

G7127-500MG

$598.00

G7127-1G

$979.00

$83.20

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About This Item

Empirical Formula (Hill Notation):
C10H15N5O11P2
CAS Number:
43139-22-6
Molecular Weight:
443.20
MDL number:
MFCD00070121
UNSPSC Code:
41106305
PubChem Substance ID:
24895291
NACRES:
NA.51

Key Documents

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Product Name

Guanosine 5′-diphosphate sodium salt, Type I, ≥96% (HPLC)

biological source

synthetic (organic)

Quality Level

300

type

Type I

assay

≥96% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1

InChI

1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;

InChI key

PVMPTWQLNDHIEV-UHFFFAOYSA-N

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Guanosine 5′-diphosphate sodium salt Type I, ≥96% (HPLC)

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Sigma-Aldrich

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Guanosine 5′-diphosphate tris salt from Saccharomyces cerevisiae

Guanosine 5′-triphosphate sodium salt solution HPLC purified, aqueous solution for RNA polymerase transcription

Sigma-Aldrich

G3776

Guanosine 5′-triphosphate sodium salt solution

Guanosine 5′-diphosphate disodium salt ≥90% (HPLC)

Sigma-Aldrich

51060

Guanosine 5′-diphosphate disodium salt

biological source

synthetic (organic)

biological source

-

biological source

Porcine brain, bacterial (Corynebacterium), yeast

biological source

Porcine brain, microbial (Corynebacterium sp), synthetic

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

100

form

powder

form

-

form

liquid

form

powder

assay

≥96% (HPLC)

assay

≥92.5%

assay

≥95% (HPLC)

assay

≥90% (HPLC)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

Guanosine 5′-diphosphate sodium salt has been used:
  • in GTP-γ-35S functional assays[1]
  • in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding[2]
  • in the expression and purification of recombinant proteins[3]

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000517335
0000517335
0000504200
0000504204
0000504199

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María-de-Los-Angeles Andrade-Oliva et al.
Environmental toxicology and pharmacology, 60, 58-65 (2018-04-17)
Male Sprague-Dawley rats (8-9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370-445 μg/m3). In membranes from rat prefrontal cortex
Neuropeptide Y promotes neurogenesis in murine subventricular zone
Agasse F, et al.
Stem Cells, 26(6), 1636-1645 (2008)
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT 1A agonist, as a putative mediator of quetiapine's antidepressant activity
Jensen N H, et al.
Neuropsychopharmacology, 33(10), 2303-2303 (2008)
A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease
Yanagisawa M, et al.
The Journal of Biological Chemistry, 283(26), 18344-18354 (2008)
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Scientific reports, 8(1), 8965-8965 (2018-06-14)
Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pKa)
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Protocols

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

Related Content

Product Information Sheet - G7127

Product Information Sheet

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