GW21258
Anti-PPARγ antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Peroxisome proliferator-activated receptor γ
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Species reactivity:
rat, human, mouse
Citations:
5
Technique(s):
western blot: suitable
Uniprot accession no.:
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biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-21258
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPARG(5468)
1 of 4
This Item | SAB4502262 | AV32880 | HPA051239 |
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form IgG fraction of antiserum | antibody form affinity isolated antibody |
| biological source chicken | biological source rabbit | biological source rabbit | biological source rabbit |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| technique(s) western blot: suitable | technique(s) ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000 | technique(s) immunohistochemistry: suitable, western blot: suitable | technique(s) immunofluorescence: 0.25-2 μg/mL |
Application
Anti-PPARγ antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Peroxisome proliferator-activated receptor γ(PPAR-γ or PPARG) is a type II nuclear receptor encoded by the PPARG gene in humans. PPARs are ligand-activated transcription factors of the nuclear hormone receptor superfamily. PPARγ is expressed as two isoforms, PPARγ2 and PPARγ1. PPARγ2 is expressed at high levels in the adipose tissues, whereas PPARγ1 has a broader expression pattern. PPARγ2 in skeletal muscle can promote conversion of subcutaneous fat to brown fat formation leading to increased energy metabolisms and combating obesity. PPARγ mRNA is expressed in humans in spleen, bone marrow, liver, testis, skeletal muscle and brain, in addition to fat.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Immunogen Sequence: GI # 4826930, sequence 1-110
Recombinant peroxisome proliferative activated receptor gamma, isoform 1
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Ying Zhou et al.
Biochemical and biophysical research communications, 446(4), 959-964 (2014-03-20)
Brown adipose tissue (BAT) is specialized to dissipate energy as heat, therefore reducing fat deposition and counteracting obesity. Brown adipocytes arise from myoblastic progenitors during embryonic development by the action of transcription regulator PRDM16 binding to PPARγ, which promotes BAT-like
Jaakko L O Pohjoismäki et al.
Nucleic acids research, 40(14), 6595-6607 (2012-04-18)
Cardiomyocyte development in mammals is characterized by a transition from hyperplastic to hypertrophic growth soon after birth. The rise of cardiomyocyte cell mass in postnatal life goes along with a proportionally bigger increase in the mitochondrial mass in response to
Liliane Michalik et al.
Pharmacological reviews, 58(4), 726-741 (2006-11-30)
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the DNA-binding domain and ligand- and cofactor-binding domain.
Juan Pablo Lezana et al.
Developmental neurobiology, 76(6), 688-701 (2015-10-09)
PPARγ is a ligand-activated nuclear receptor best known for its involvement in adipogenesis and glucose homeostasis. PPARγ activity has also been associated with neuroprotection in different neurological disorders, but the mechanisms involved in PPARγ effects in the nervous system are
A Elbrecht et al.
Biochemical and biophysical research communications, 224(2), 431-437 (1996-07-16)
We describe the molecular cloning and expression of cDNAs encoding human PPAR gamma 1 and PPAR gamma 2. Our sequences are distinct from the published sequence at 3 positions, resulting in nonconservative amino acid substitutions. In humans, PPAR gamma mRNA
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