MilliporeSigma
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GW22757

Sigma-Aldrich

Anti-AKT1 (ab1) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

MDL number:
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

manufacturer/tradename

Genway 15-288-22757

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... AKT1(207)

Immunogen

Immunogen Sequence: GI # 62241011, sequence 2-200
Recombinant serine/threonine protein kinase

Application

Anti-AKT1 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

RAC-α serine/threonine-protein kinase is an enzyme encoded by the AKT1 gene in humans and is a member of the serine/threoine AGC protein kinase family. It is an intracellular signal transduction protein activated by growth hormones and its pathway is critically involved in cancer cell growth, proliferation, metabolism, invasion and survival. AKT1 acts as a potential target for cancer gene therapy. The gene is frequently activated in a variety of cancer types and is accepted as a promising anticancer therapeutic target.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Quotes and Ordering

Xiaoting Wang et al.
Journal of cancer research and clinical oncology, 140(8), 1399-1411 (2014-04-17)
v-akt Murine thymoma viral oncogene homolog (AKT) pathway is critically involved in cancer cell growth, invasion, and survival. We examined the correlation between the genetic variations in molecules of AKT pathway and clinical outcomes of gastric cancer. Six single nucleotide
F Yang et al.
Cell death & disease, 5, e1114-e1114 (2014-03-15)
The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target. However, the relief of feedback inhibition and enhancement of other survival pathways often attenuate the anticancer effects of AKT inhibitors. These compensatory mechanisms are very complicated and
Min Zhang et al.
Clinical laboratory, 60(1), 1-8 (2014-03-08)
AKT1 is a member of the serine/threoine AGC protein kinase family involved in cancer's metabolism, growth, proliferation, and survival. It is a potential target for cancer gene therapy. In the present study, we used DNAzyme and siRNA technology to inhibit
Alpaslan Mayadagli et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19(1), 157-163 (2014-03-25)
Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has
Mariëtte E G Kranendonk et al.
Obesity (Silver Spring, Md.), 22(10), 2216-2223 (2014-07-22)
Insulin resistance (IR) is a key mechanism in obesity-induced cardiovascular disease. To unravel mechanisms whereby human adipose tissue (AT) contributes to systemic IR, the effect of human AT-extracellular vesicles (EVs) on insulin signaling in liver and muscle cells was determined.

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