GW22766

Sigma-Aldrich

Anti-FAS (ab1) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-CD95
MDL number:

biological source

chicken

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

manufacturer/tradename

Genway 15-288-22766

application(s)

western blot: suitable

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FAS(355)

General description

The FAS receptor (FasR) is a protein encoded by the TNFRSF6 gene in humans and is mapped to chromosomal band 10q24.1. It is a cell surface antigen expressed on a variety of normal and malignant cells.

Immunogen

Recombinant tumor necrosis factor receptor superfamily, member 6 isoform 1
Immunogen Sequence: GI # 4507583, sequence 21-165

Application

Anti-FAS (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The FAS receptor (FasR) is associated with programmed cell death (apoptosis). It functions as an apoptosis-signaling cell surface Ag. Mutation of the gene or defective FAS signaling may render the T-cell lymphoblastic lymphomas (T-LBLs) tumor cells resistant to apoptotic cell death.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

I Cascino et al.
Journal of immunology (Baltimore, Md. : 1950), 154(6), 2706-2713 (1995-03-15)
Fas/Apo-1 molecule is an apoptosis-signaling cell surface Ag belonging to the TNFR family. To investigate the possibility that soluble forms of the Fas receptor are expressed in human cells, we analyzed Fas mRNA transcripts obtained from activated peripheral mononuclear cells...
P Lichter et al.
Genomics, 14(1), 179-180 (1992-09-01)
The APO-1 (APT) antigen is a cell surface antigen expressed on a variety of normal and malignant cells. Binding of anti-APO-1 antibody to the APO-1 antigen induces programmed cell death (apoptosis). The APO-1 antigen shows homology to the members of...
Assignment of the human Fas antigen gene (Fas) to 10q24.1.
J Inazawa et al.
Genomics, 14(3), 821-822 (1992-11-01)
Jin Taek Hwang et al.
Acta poloniae pharmaceutica, 71(1), 35-38 (2014-05-02)
In this study, the adipogenesis-suppressing effect of 3,5-dimethoxy(4-methoxyphenyl)benzamide (DMPB), a derivative of the anti-obesity substance resveratrol, was measured in 3T3-L1 cells. The results show that DMPB effectively suppressed the hormone-induced differentiation of 3T3-L1 cells, compared to resveratrol at the same...
Xiao Yang Wang et al.
Clinical & experimental ophthalmology, 42(6), 529-538 (2013-11-15)
The aim of the study was to investigate, using a native mitomycin-C-resistant human Tenon's fibroblast cell line, the possibility that interferon-alpha and gamma could be used with Fas agonists as an alternative anti-fibrotic strategy to mitomycin-C in trabeculectomy. A clinically...

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