The best practice for item H0915, Hydroxychloroquine sulfate, involves preparing the stock solution fresh before use. Although information about the stability of small molecules in solution is rare, it is generally recommended to store in PBS at -20°C. To prevent repeated freeze-thaw cycles, it is advisable to aliquot into working volumes. Additionally, the effect of storing the stock solution on compound performance should be evaluated for each specific application. When used as a cell culture supplement, the stock solution should be diluted into the culture medium immediately before use.
H0915
Hydroxychloroquine sulfate
≥98% (HPLC), powder, anti-inflammatory
Synonym(s):
Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
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$141.00
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About This Item
Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
Molecular Weight:
433.95
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Hydroxychloroquine sulfate, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to off-white
solubility
H2O: >20 mg/mL
SMILES string
OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI key
JCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Information
human ... TLR7(51284), TLR9(54106)
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Related Categories
1 of 4
This Item | 1327000 | BP1100 | 90527 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay - | assay ≥95.0% (HPLC) |
| form powder | form - | form solid | form - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage condition protect from light | storage condition protect from light | storage condition - | storage condition - |
| solubility H2O: >20 mg/mL | solubility chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble, water: soluble | solubility water: soluble | solubility - |
| color white to off-white | color white to off-white | color off-white | color white to off-white |
Application
Hydroxychloroquine sulfate has been used:
- as an inhibitor of autophagy to treat cells for apoptosis assay[1] to study the role of pirarubicin induced autophagy in bladder cancer cell line[2]
- to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay[3]
- to inhibit lysosome fusion with the autophagosome[4]
Biochem/physiol Actions
Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.[5]
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor.
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Pharmacotherapeutics for Advanced Practice, 536, 435-435 (2006)
Fluorescence Microscopy Analysis of Drug Effect on Autophagosome Formation
Stankov M, et al.
Antimicrobial agents and chemotherapy (2013)
The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells
Schott CR, et al.
Testing, 13(10), e0206427-e0206427 (2018)
Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells
Li K, et al.
Biochemical and Biophysical Research Communications, 460(2), 380-385 (2015)
Barry Ladizinski et al.
Journal of the American Academy of Dermatology, 68(5), 749-755 (2013-02-05)
Frontal fibrosing alopecia (FFA) is a type of scarring hair loss primarily observed in postmenopausal women and characterized by fronto-tempero-parietal hairline recession, perifollicular erythema, and loss of eyebrows. The incidence is unknown, but the number of women presenting with this
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How should stock solutions of H0915, Hydroxychloroquine sulfate, be stored after reconstituting in water or PBS?
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