CAS Number:
EC Number:
PubChem Substance ID:

Quality Level

biological source

synthetic (organic)


≥98% (TLC)



mol wt

estimated mol wt ~1396 Da (Average degree of substitution is 0.5-1.3 unit of 2-hydroxypropyl (C3H7O) per glucose unit)


H2O: soluble

storage temp.

room temp

SMILES string




InChI key


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General description

Cyclodextrins are cyclic oligosaccharides consisting of 6, 7, or 8 glucopyranose units, usually referred to as α-, β-, or γ-cyclodextrins, respectively. These compounds have rigid doughnut-shaped structures making them natural complexing agents. The unique structures of these compounds owe their stability to intramolecular hydrogen bonding between the C2- and C3-hydroxyl groups of neighboring glucopyranose units. The molecule takes on the shape of a torus with the C2- and C3-hydroxyls located around the larger opening and the more reactive C6-hydroxyl aligned around the smaller opening. The arrangement of C6-hydroxyls opposite the hydrogen bonded C2- and C3-hydroxyls forces the oxygen bonds into close proximity within the cavity, leading to an electron rich, hydrophobic interior. The size of this hydrophobic cavity is a function of the number of glucopyranose units forming the cyclodextrin.

The solubility of natural cyclodextrins is very poor. In the late 1960′s, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.

Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, ß-cyclodextrin is most commonly used as a complexing agent.


(2-Hydroxypropyl)-β-cyclodextrin has been used:
  • to investigate its effects on cholesterol homeostasis
  • for the kindling procedure in mice and hippocampal electrographic analysis
  • to improve poor prepulse inhibition (PPI) in mice
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.


5, 5×5, 100 g in poly bottle


13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Cornelius Engelmann et al.
Journal of hepatology, 73(1), 102-112 (2020-01-29)
Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Herein, we assess whether inhibiting TLR4 signaling can ameliorate liver failure and serve as a potential treatment. Circulating...
Variables affecting prepulse inhibition of the startle reflex and the response to antipsychotics in DBA/2NCrl mice
Flood DG, et al.
Psychopharmacology, 195(2), 203-211 (2007)
Platelet-activating factor receptor antagonism targets neuroinflammation in experimental epilepsy
Musto AE and Samii M
Epilepsia, 52(3), 551-561 (2011)
Cathelijne Heymans et al.
Nutrients, 12(5) (2020-05-10)
Chorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis (NEC). In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. Plant sterols are a...
Normalization of cholesterol homeostasis by 2-hydroxypropyl-beta-cyclodextrin in neurons and glia from Niemann-Pick C1-deficient mice
Peake KB and Vance JE
The Journal of Biological Chemistry, jbc-M111 (2012)
Solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl beta-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.
Read More
Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.
Read More

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