H1252

Sigma-Aldrich

Homovanillic acid

Fluorimetric reagent

Synonym(s):
4-Hydroxy-3-methoxyphenylacetic acid, HVA
Linear Formula:
HOC6H3(OCH3)CH2CO2H
CAS Number:
Molecular Weight:
182.17
Beilstein/REAXYS Number:
2213447
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

assay

>99% (TLC)

form

powder

application(s)

hematology: suitable
histology: suitable

mp

142-145 °C (lit.)

solubility

ethanol: 50 mg/mL, colorless to light yellow

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

COc1cc(CC(O)=O)ccc1O

InChI

1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)

InChI key

QRMZSPFSDQBLIX-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Homovanillic acid has been used as a standard in HPLC analysis.

Packaging

100, 250 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

Metabolite of dihydroxyphenylacetic acid (DOPAC) by catechol O-methyltransferase; reagent for the fluorimetric determination of glucose oxidase and other oxidative enzymes.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H1252.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Forced nonuse in unilateral parkinsonian rats exacerbates injury.
Tillerson JL
The Journal of Neuroscience, 22, 6790-6790 (2002)
Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease.
Tillerson JL
Neuroscience, 119, 899-899 (2003)
Tashjian AH and Armstrong EJ
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2011)
Practical Fluorescence (1990)
Michèl A Willemsen et al.
Brain : a journal of neurology, 133(Pt 6), 1810-1822 (2010-05-01)
Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical phenotypes and rational diagnostic and therapeutic approaches for...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service