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H1753

Hydralazine hydrochloride

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

Synonym(s):

1-Hydrazinophthalazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H8N4 · HCl
CAS Number:
304-20-1
Molecular Weight:
196.64
NACRES:
NA.77
PubChem Substance ID:
24278461
UNSPSC Code:
12352200
EC Number:
206-151-0
MDL number:
MFCD00135998
Assay:
≥99% (TLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Hydralazine hydrochloride,

InChI key

SECXUXOCDLQOBI-MKFZHGHUSA-N

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

SMILES string

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

biological source

synthetic (organic)

assay

≥99% (TLC)

form

powder

mp

273 °C

solubility

water: 50 mg/mL

Quality Level

100

Gene Information

human ... MAOA(4128), MAOB(4129)

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This Item
P8013C8138D7909
Hydralazine hydrochloride

Sigma-Aldrich

H1753

Hydralazine hydrochloride

Pargyline hydrochloride

Sigma-Aldrich

P8013

Pargyline hydrochloride

Chlorpromazine hydrochloride ≥98% (TLC)

Sigma-Aldrich

C8138

Chlorpromazine hydrochloride

Dicyclomine hydrochloride ≥99% (TLC), powder

Sigma-Aldrich

D7909

Dicyclomine hydrochloride

form

powder

form

powder or crystals

form

powder

form

powder

assay

≥99% (TLC)

assay

98% (TLC)

assay

≥98% (TLC)

assay

≥99% (TLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: 50 mg/mL

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL

solubility

H2O: 50 mg/mL

biological source

synthetic (organic)

biological source

synthetic

biological source

-

biological source

-

mp

273 °C

mp

160-163 °C (lit.)

mp

194-196 °C

mp

-

Application

Hydralazine hydrochloride has been used:
  • as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats[1]
  • as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury[2]
  • as a vasodilator to study its effects on insulin secretion and glucose tolerance[3]

Biochem/physiol Actions

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.[4]
Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ0814
MKCT3552
MKCQ8899
MKCR9220
MKCQ2237

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Nadine S Sauter et al.
Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
Edmond A Rogers et al.
Scientific reports, 12(1), 11838-11838 (2022-07-14)
While clinical observations have confirmed a link between the development of neurodegenerative diseases and traumatic brain injuries (TBI), there are currently no treatments available and the underlying mechanisms remain elusive. In response, we have developed an in vitro pendulum trauma
Ruijia Feng et al.
Gut microbes, 16(1), 2390164-2390164 (2024-08-18)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model
Dirk Westermann et al.
Basic research in cardiology, 107(6), 308-308 (2012-11-03)
Sildenafil inhibits cyclic GMP-specific phosphodiesterase type-5A (PDE5A) and can prevent cardiac hypertrophy and left ventricular (LV) dysfunction in mice subjected to severe pressure-overload. The pathophysiological role of sildenafil in adverse remodeling in the hypertensive heart after chronic renin-angiotensin aldosterone system
Mara Colzani et al.
ChemMedChem, 11(16), 1778-1789 (2016-02-19)
Reactive carbonyl species (RCS) are endogenous or exogenous byproducts involved in the pathogenic mechanisms of different oxidative-based disorders. Detoxification of RCS by carbonyl quenchers is a promising therapeutic strategy. Among the most studied quenchers are aminoguanidine, hydralazine, pyridoxamine, and carnosine;
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