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MilliporeSigma

H2292

Sigma-Aldrich

Histone H3.1 human

Synonym(s):

Histone, Human

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100 μG
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About This Item

CAS Number:
1523001-32-2
UNSPSC Code:
12352202
NACRES:
NA.25

Key Documents

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biological source

human

Quality Level

200

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

technique(s)

MALDI-TOF: suitable

UniProt accession no.

P68431

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H3C1(8350)

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This Item
H2167H2042H2542
Histone H3.1 human

Sigma-Aldrich

H2292

Histone H3.1 human

Histone H2B human

Sigma-Aldrich

H2167

Histone H2B human

Histone H2A human

Sigma-Aldrich

H2042

Histone H2A human

Histone H3.3 human

Sigma-Aldrich

H2542

Histone H3.3 human

biological source

human

biological source

human

biological source

human

biological source

human

technique(s)

MALDI-TOF: suitable

technique(s)

-

technique(s)

-

technique(s)

-

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

concentration

1 mg/mL

concentration

1 mg/mL

concentration

1 mg/mL

concentration

1 mg/mL

form

liquid

form

liquid

form

liquid

form

liquid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Histone H3.1 is a histone H3 variant.[1] It differs from H3.2 with residue 96 being a cysteine instead of serine.[2] H3.1 is a replication-dependent histone and is a component of nucleosomes during the S-phase.[3]

Application

Histone H3.1 human has been used in in vitro Schizosaccharomyces pombe Set7 histone methyltransferase assay for matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) studies.[4]

Biochem/physiol Actions

Histone H3.1 human (H3.1) undergoes a majority of post-translational modification especially acetylation and demethylation in lysine 14 and 9 respectively.[1] During differentiation, the levels of H3.1 transcripts decrease as cell division slows down.[2] The incorporation of H3.1 into chromatin is mediated by a chaperone, chromatin assembly factor (CAF-1).[1] A transversion mutation in the H3.1 may be implicated in glioma.[3]

Physical form

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000349247
0000341075
0000309409
SLCQ4379
0000294089

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Sandra B Hake et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(17), 6428-6435 (2006-03-31)
In the history of science, provocative but, at times, controversial ideas have been put forward to explain basic problems that confront and intrigue the scientific community. These hypotheses, although often not correct in every detail, lead to increased discussion that
Gang Wu et al.
Nature genetics, 44(3), 251-253 (2012-01-31)
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found
Yunpeng Shen et al.
Structure (London, England : 1993), 27(4), 631-638 (2019-02-19)
Histone methylation by histone methyltransferases (HMTases) has a key role in transcriptional regulation. Discrepancies between the known HMTases and the histone lysine methylome suggest that HMTases remain to be identified. Here we report the discovery, characterization, and crystal structure of
Hideaki Tagami et al.
Cell, 116(1), 51-61 (2004-01-14)
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3

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