H3128

Sigma-Aldrich

Calconcarboxylic acid

Synonym(s):
3-Hydroxy-4-(2-hydroxy-4-sulfo-1-naphthylazo)naphthalene-2-carboxylic acid, Patton and Reeder’s reagent, 2-Hydroxy-1-(2-hydroxy-4-sulfo-1-naphthylazo)-3-naphthoic acid
Empirical Formula (Hill Notation):
C21H14N2O7S
CAS Number:
Molecular Weight:
438.41
Beilstein/REAXYS Number:
727492
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

application(s)

hematology: suitable
histology: suitable

mp

300 °C

solubility

1 M NaOH: 10 mg/mL

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

OC(=O)c1cc2ccccc2c(N=Nc3c(O)cc(c4ccccc34)S(O)(=O)=O)c1O

InChI

1S/C21H14N2O7S/c24-16-10-17(31(28,29)30)13-7-3-4-8-14(13)18(16)22-23-19-12-6-2-1-5-11(12)9-15(20(19)25)21(26)27/h1-10,24-25H,(H,26,27)(H,28,29,30)/b23-22-

InChI key

MVQBFZXBLLMXGS-FCQUAONHSA-N

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General description

Calconcarboxylic acid is a useful indicator for calcium titrations with EDTA in the presence of magnesium. It is also required for the staining of proteins in gels.
Calconcarboxylic acid is also known as Patton-Reeder indicator and is used in the determination of calcium at pH 12. Calconcarboxylic acid is a chelating agent and is used in the preparation of chelating sorbent along with chemically modified silica LiChroprep-NH2, for trace metal analysis. Calconcarboxylic acid coupled with 3-aminopropyltriethoxysilane (APS-CCA), a fluorescent probe, facilitates the medical detection of Ca2+ ions in the blood with minimal blood backgrounds using hydrophobic hexadecyltrimethoxysilane (HDS) as substrate in fluorimetric microarray method.

Application

Calconcarboxylic acid (CCA) has been used in the preparation of poly-CCA film for leukemia diagnosis by immobilization, hybridization of DNA and detection by methylene blue and differential pulse voltammetry.

Packaging

5, 25, 100 g in glass bottle

Quality

Contains an inert diluent.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

hazcat

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Selçuk Şimşek et al.
Journal of hazardous materials, 338, 437-446 (2017-06-09)
In this study, a versatile polymeric material was synthesized by grafting Calcon Carboxylic Acid (CCA), which is known as a chelating agent for some metal ions, to polyacrylamide (PAA) structure. Thus, the adsorptive properties of inert PAA polymer were significantly...
Li N, Hefferren JJ and Li K
Quantitative Chemical Analysis (2013)
LiChroprep-NH2 modified with calconcarboxylic acid as a sorbent in trace analysis of metal ions
Kocjan R, et al.
Journal of Separation Science, 25(14), 891-896 (2002)
Patton, J. and Reeder, W.
Analytical Chemistry, 28, 1026-1026 (1956)
Separation Methods In Proteomics (2005)

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