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H3899

Sigma-Aldrich

D-Homocysteinesulfinic acid

≥98% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C4H9NO4S
CAS Number:
Molecular Weight:
167.18
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

assay

≥98% (TLC)

storage temp.

−20°C

SMILES string

NC(CCS(O)=O)C(O)=O

InChI

1S/C4H9NO4S/c5-3(4(6)7)1-2-10(8)9/h3H,1-2,5H2,(H,6,7)(H,8,9)

InChI key

PDNJLMZEGXHSCU-UHFFFAOYSA-N

Biochem/physiol Actions

Potent, fast-acting NMDA glutamate receptor agonist.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

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W Morishita et al.
Journal of neurophysiology, 82(5), 2556-2564 (1999-11-24)
Depolarization-induced suppression of inhibition (DSI) is a process whereby brief approximately 1-s depolarization to the postsynaptic membrane of hippocampal CA1 pyramidal cells results in a transient suppression of GABA(A)ergic synaptic transmission. DSI is triggered by a postsynaptic rise in [Ca(2+)](in)
Homocysteic acid, an endogenous agonist of NMDA-receptor: release, neuroactivity and localization.
M Cuénod et al.
Advances in experimental medicine and biology, 203, 253-262 (1986-01-01)
H Sugiyama et al.
Neuron, 3(1), 129-132 (1989-07-01)
Three major subtypes of glutamate receptors that are coupled to cation channels are known. Recently an additional subtype that is coupled to G proteins and stimulates inositol phospholipid metabolism (the metabotropic glutamate receptor) has been proposed. The pharmacological characteristics of
M Bouvier et al.
The Journal of physiology, 444, 441-457 (1991-12-01)
1. The effect of sulphur-containing analogues of glutamate and aspartate on the membrane current of glial cells was studied by whole-cell clamping Müller cells isolated from the salamander retina. 2. L-Cysteic acid (CA), L-cysteinesulphinic acid (CSA), L-homocysteic acid (HCA), L-homocysteinesulphinic
G A Thompson et al.
Neuropharmacology, 34(8), 857-863 (1995-08-01)
Depolarizations induced by a range of amino acids including some sulphur-containing excitatory transmitter candidates were evoked from motoneurones in the neonatal rat spinal cord under conditions that precluded activation of known ionotropic glutamate receptors. The responses could be partially and

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