The stability of this product in solution after reconstitution has not been specifically determined. However, it is recommended that solutions be stored in working aliquots at −20°C. This practice is considered optimal for maintaining stability, but no exact shelf life duration is provided after reconstitution.
H4001
Hydrocortisone
synthetic (organic), ≥98% (HPLC), anti-inflammatory agent, powder
Hydrocortisone
Synonym(s):
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
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1 G
$39.30
5 G
$143.00
10 G
$277.00
25 G
$468.00
100 G
$1,410.00
About This Item
Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
Molecular Weight:
362.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-020-1
MDL number:
Beilstein/REAXYS Number:
1354819
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Product Name
Hydrocortisone, ≥98% (HPLC)
InChI key
JYGXADMDTFJGBT-VWUMJDOOSA-N
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
biological source
synthetic (organic)
sterility
non-sterile
assay
≥98% (HPLC)
form
powder
mp
211-214 °C (lit.)
solubility
water: 0.28 g/L at 25 °C
application(s)
cell analysis
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (TLC) | assay - | assay ≥99% (HPLC) |
| form powder | form solid | form liquid | form solid |
| Quality Level 300 | Quality Level 100 | Quality Level 500 | Quality Level 100 |
| storage temp. room temp | storage temp. 10-30°C | storage temp. −20°C | storage temp. 10-30°C |
| solubility water: 0.28 g/L at 25 °C | solubility ethanol: 15 mg/mL | solubility - | solubility DMSO: 10 mg/mL, ethanol: soluble |
| shipped in ambient | shipped in ambient | shipped in dry ice | shipped in ambient |
Biochem/physiol Actions
Primary glucocorticoid secreted by the adrenal cortex.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Product No.
Description
Pricing
signalword
Danger
hcodes
Hazard Classifications
Repr. 1A - STOT RE 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
Marianne Oksnes et al.
The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
Rachel Yehuda et al.
The American journal of psychiatry, 171(8), 872-880 (2014-05-17)
Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
K J Rademaker et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
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What is the shelf life of reconstituted product at 4C, -20C, and -80C?
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