Skip to Content
MilliporeSigma

H6649

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

Slide 1 of 1
Sign In to View Organizational & Contract Pricing

Select a Size

0.1 MG

$349.00

1 MG

$1,003.00

$349.00

Available to ship TODAYDetails

Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C30H42N2O9
CAS Number:
70563-58-5
Molecular Weight:
574.66
Beilstein/REAXYS Number:
4834067
MDL number:
MFCD00151702
UNSPSC Code:
12352200
PubChem Substance ID:
24895756
NACRES:
NA.77

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

Streptomyces hygroscopicus

Quality Level

200

assay

≥95% (HPLC)

form

powder

color

yellow

solubility

DMSO: 7.5 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

InChI

1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

InChI key

MCAHMSDENAOJFZ-BVXDHVRPSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
H9773H3274A3835
Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder

Sigma-Aldrich

H6649

Herbimycin A from Streptomyces hygroscopicus

Hygromycin B from Streptomyces hygroscopicus suitable for plant cell culture, BioReagent, ≥60% (HPLC), lyophilized powder

Sigma-Aldrich

H9773

Hygromycin B from Streptomyces hygroscopicus

Hygromycin B from Streptomyces hygroscopicus powder, BioReagent, suitable for cell culture, suitable for insect cell culture

Sigma-Aldrich

H3274

Hygromycin B from Streptomyces hygroscopicus

Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

Sigma-Aldrich

A3835

Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

assay

≥95% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

lyophilized powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 7.5 mg/mL

solubility

H2O: soluble 50 mg/mL, ethanol: soluble, methanol: soluble

solubility

H2O: 50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.)

solubility

-

color

yellow

color

faintly brown to brown, white to beige

color

faintly brown to brown, white to beige

color

-

General description

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic.[1] It is an analog of geldanamycin.[2]

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells[3] and rat intestinal epithelial cells.[4] It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.[1]

Biochem/physiol Actions

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.
Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.[1]

Disclaimer

Hygroscopic and photosensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SLCL1131
SLCK3695
SLCF6017
SLBS2836V
SLBQ3791V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

E M Connolly et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 25(1), 40-47 (2003-01-15)
intimal hyperplasia (IH) is a major cause of re-stenosis post-vascular intervention. Induction of heat shock proteins (HSPs), by thermal pre-conditioning, reduces IH. Our aim was to investigate the effect of the pharmacological HSP inducer herbimycin A on IH in the
M A Davis et al.
Toxicology and applied pharmacology, 161(1), 59-74 (1999-11-24)
It is important to understand the mechanisms by which phosphorylation-dependent events play a role in regulation of apoptosis in toxicant-metabolizing organs such as the kidney. Our previous work demonstrated that the toxicant and phosphatase inhibitor okadaic acid induces apoptosis of
K Nagaishi et al.
Journal of cellular physiology, 180(3), 345-354 (1999-08-03)
We previously reported that a 21-kDa phosphoprotein may play an important role in superoxide production through dephosphorylation by neutrophillike differentiated HL-60 cells (Suzuki et al., 1995, Biochim Biophys Acta 1266: 261-267). The phosphoprotein was identified as cofilin, an actin-binding protein
T Zakar et al.
Canadian journal of physiology and pharmacology, 77(2), 138-142 (1999-10-27)
Human amnion cells in primary culture respond to glucocorticoids in a characteristic fashion by the increased expression of the inducible prostaglandin endoperoxide H synthase isoenzyme, PGHS-2. Since PGHS-2 induction by agonists generally involves tyrosine kinases, we examined the possibility that
Alexander Epshtein et al.
Archives of virology, 154(1), 55-63 (2008-12-11)
Expression of the E6 oncoprotein of human papillomavirus (HPV) 16 in primary human keratinocytes (PHKs) was previously shown to significantly reduce apoptosis. This could be due to increased cell adhesion. Adhesion ability was tested by seeding cells on tissue culture
View All Related Papers

Related Content

Product Information Sheet - H6649

Product Information Sheet

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service