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H6883

Sigma-Aldrich

3-(N,N-Dimethylpalmitylammonio)propanesulfonate

≥98% (TLC)

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Synonym(s):
3-(N,N-Dimethylhexadecylammonio)propanesulfonate, 3-(Hexadecyldimethylammonio)propanesulfonate, 3-(Palmityldimethylammonio)propanesulfonate, Palmityl sulfobetaine, SB3-16
Linear Formula:
CH3(CH2)15N+(CH3)2CH2CH2CH2SO3-
CAS Number:
Molecular Weight:
391.65
Beilstein:
4149854
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

description

zwitterionic

Assay

≥98% (TLC)

mol wt

micellar avg mol wt 60,700

aggregation number

155

technique(s)

electrophoresis: suitable
mass spectrometry (MS): suitable
thin layer chromatography (TLC): suitable

conductivity

≤10 μmho per cm at 24 °C (0.05 M aqueous solution)

CMC

0.01-0.06 mM (20-25°C)

application(s)

cell analysis

SMILES string

CCCCCCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O

InChI

1S/C21H45NO3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22(2,3)20-18-21-26(23,24)25/h4-21H2,1-3H3

InChI key

TUBRCQBRKJXJEA-UHFFFAOYSA-N

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This Item
T0807T776340772
assay

≥98% (TLC)

assay

≥99% (TLC)

assay

≥99% (TLC)

assay

≥98.0% (TLC)

mol wt

micellar avg mol wt 60,700

mol wt

micellar avg mol wt 30,200

mol wt

micellar avg mol wt 30,200

mol wt

micellar avg mol wt 30,200

aggregation number

155

aggregation number

83

aggregation number

83

aggregation number

83

technique(s)

electrophoresis: suitable, mass spectrometry (MS): suitable, thin layer chromatography (TLC): suitable

technique(s)

electrophoresis: suitable, ion chromatography: suitable

technique(s)

electrophoresis: suitable

technique(s)

nucleic acid detection: suitable, protein purification: suitable, protein quantification: suitable

CMC

0.01-0.06 mM (20-25°C)

CMC

0.1-0.4 mM (20-25°C)

CMC

0.1-0.4 mM (20-25°C)

CMC

0.1-0.4 mM (20-25°C)

General description

3-(N,N-Dimethylpalmitylammonio)propanesulfonate is a zwitterionic detergent.

Application

3-(N,N-Dimethylpalmitylammonio)propanesulfonate has been used in a study to assess the characterization of rat dihydroceramide desaturase. It has also been used in a study to investigate the inhibition of mitochondrial carnitine–acylcarnitine translocase by sulfobetaines. It is also used for extraction of proteins for analysis by chromatography, mass spectroscopy, and electrophoretic methods.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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R J Barry et al.
The Journal of biological chemistry, 264(16), 9231-9238 (1989-06-05)
Studies reported previously from this laboratory have demonstrated that membranes from the pigment epithelium of the vertebrate eye can transform free all-trans-retinol to 11-cis-retinol as well as 11-cis- and all trans-retinyl esters (Bernstein, P. S., Law, W. C., and Rando
H Erdjument-Bromage et al.
Journal of chromatography. A, 826(2), 167-181 (1999-01-01)
Mass spectrometry occupies a central position in most current protein identification schemes. So-called 'mass fingerprinting' techniques rely on composite mass patterns of proteolytic fragments, or dissociation products thereof, to query databases. Keys to successful analysis of ever smaller amounts are
R Parvin et al.
Canadian journal of biochemistry, 58(10), 822-830 (1980-10-01)
Sulfobetaines (N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonates) have been identified as relatively specific and selective inhibitors of mitochondrial carnitine-acylcarnitine translocase. Thus, sublytic concentrations of sulfobetaines (alkyl = octyl to tetradecyl) inhibit the respiration of rat heart mitochondria supported by added acylcarnitines or pyruvate plus malonate
C Causeret et al.
Lipids, 35(10), 1117-1125 (2000-12-05)
The introduction of the double bond in the sphingoid backbone of sphingolipids occurs at the level of dihydroceramide via an NADPH-dependent desaturase, as discovered in permeabilized rat hepatocytes. In the rat, the enzyme activity, which has now been further characterized
M Lui et al.
Analytical biochemistry, 241(2), 156-166 (1996-10-15)
We have analyzed the efficacies of seven different organic solvents, 13 organic bases, and 17 detergents to dissociate electroblotted proteins from nitrocellulose. Most efficient were a 1% piperidine-40% acetonitrile mixture and 1% concentrations of either cetyltrimethylammonium bromide or several polyoxyethylene

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