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H7041

Sigma-Aldrich

Interleukin-2 human

IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

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Synonym(s):
Interleukin-2, T-cell growth factor
MDL number:
NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in HEK 293 cells

form

lyophilized powder

potency

≤5.0 ng/mL ED50

quality

endotoxin tested

mol wt

monomer 15 kDa (glycosylated)

packaging

pkg of 5X10 μg
pkg of 10 μg
pkg of 100 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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This Item
I2644I790857600
Interleukin-2 human IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

Sigma-Aldrich

H7041

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

I2644

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

I7908

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

57600

Interleukin-2 human

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

recombinant

expressed in Pichia pastoris

recombinant

expressed in E. coli

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

liquid

potency

≤5.0 ng/mL ED50

potency

≤700 EC50

potency

-

potency

-

mol wt

monomer 15 kDa (glycosylated)

mol wt

15.5 kDa

mol wt

predicted mol wt ~15 kDa

mol wt

Mr ~15500

packaging

pkg of 5X10 μg, pkg of 10 μg, pkg of 100 μg

packaging

pkg of 5X10 μg, pkg of 10 μg

packaging

pkg of 10KU

packaging

vial of 1 mL

General description

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Application

Interleukin-2 human has been used to culture peripheral blood mononuclear cells (PBMC). It has been used to activate effector cell (PBMC) and to study antibody-dependent cell-mediated cytotoxicity.

Biochem/physiol Actions

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the formation and essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. IL-2 mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Preparation Note

Human Interleukin-2 (IL-2) expressed in human HEK 293 cells is a glycosylated monomer with a molecular mass of 15 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Analysis Note

The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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