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H7660

Heregulin-β1 (EGF Domain) human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

HRG-β1

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10 μg

Available to ship TODAYfromMILWAUKEE

$293.00
50 μg

Available to ship TODAYfromMILWAUKEE

$912.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD03457066

$293.00

Available to ship TODAYDetails

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biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

<0.50 ng/mL

mol wt

predicted mol wt 8 kDa

packaging

pkg of 10 and 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

color

white

UniProt accession no.

Q02297

storage temp.

−20°C

Gene Information

human ... NRG1(3084)

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

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Sigma-Aldrich

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assay

≥98% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

form

lyophilized powder

form

buffered aqueous glycerol solution

form

lyophilized powder

form

powder

impurities

endotoxin, tested

impurities

-

impurities

≤1 EU/μg

impurities

≤1 EU/μg

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000254888
0000254887
0000490171
0000490172
0000254887

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Related Content

Data Sheet - H7660

Instructions

Wei Tan et al.
The Journal of biological chemistry, 282(33), 24343-24351 (2007-06-15)
Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. Recently, altered expression of a novel isoform (type IV) in the brain has
Neural grafts containing exosomes derived from Schwann cell-like cells promote peripheral nerve regeneration in rats.
Hu, et al.
Burns & trauma, 11, tkad013-tkad013 (2023)
A M Addington et al.
Molecular psychiatry, 12(2), 195-205 (2006-10-13)
Childhood-onset schizophrenia (COS), defined as onset of psychosis by the age of 12, is a rare and malignant form of the illness, which may have more salient genetic influence. Since the initial report of association between neuregulin 1 (NRG1) and
View All Related Papers

Global Trade Item Number

SKUGTIN
H7660-50UG04061833804209
H7660-10UG04061833804193

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