H8017

Sigma-Aldrich

Hydroxocobalamin acetate

vitamin B12 analog

Synonym(s):
Vitamin B12a acetate
Empirical Formula (Hill Notation):
C64H91CoN13O16P
CAS Number:
Molecular Weight:
1388.39
EC Number:
MDL number:
eCl@ss:
34058004
PubChem Substance ID:
NACRES:
NA.79

Quality Level

biological source

synthetic (organic)

assay

≥95 (HPLC)

form

powder

application(s)

HPLC: suitable

color

red to brown

storage temp.

2-8°C

SMILES string

CC(CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N=C1C(C)=C3N=C(C=C4N=C(C(C)=C5[C@@H](CCC(N)=O)[C@](C)(CC(N)=O)[C@@]2(C)N5[Co]OC(C)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78

InChI

1S/C62H90N13O14P.C2H4O2.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2(3)4;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3,(H,3,4);/q;;+2/p-3/t31?,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1

InChI key

QHSPIHUMLGFPKX-WYVZQNDMSA-K

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Hydroxocobalamin is an analog of vitamin B12 with OH as an alkyl group. Vitamin B12 cobalamin refers to a group of chemically-related cobalt containing molecules.

Packaging

1 g in glass bottle
250 mg in glass bottle

Biochem/physiol Actions

Vitamin B12 cobalamin is involved in DNA synthesis and fatty acid synthesis. It also plays a vital role as a coenzyme in the conversion of mitochondrial methylmalonyl co-enzyme A to succinyl co-enzyme A. Vitamin B12 cobalamin is also involved in neurotransmitter synthesis and erythropoiesis. It also functions in the synthesis and maintenance of myelin sheath. Hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Precautionary Statements

hazcat

Carc. 2

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Hydroxocobalamin association during cell culture results in pink therapeutic proteins
MAbs, 5(6), 974-981 (2013)
Photodegradation of cobalamins in aqueous solutions and in human blood
Juzeniene A and Nizauskaite Z
Journal of Photochemistry and Photobiology. B, Biology, 122(21), 7-14 (2013)
Iron, vitamin B12 and folate
Moll R and Davis B
Medicine, 45(4), 198-203 (2017)
The effect of vitamin B12 deprivation on the enzymes of fatty acid synthesis
Frenkel E P, et al.
The Journal of Biological Chemistry, 248(21), 7540-7546 (1973)
Ruma Banerjee
ACS chemical biology, 1(3), 149-159 (2006-12-14)
Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the cell uses a collision-based strategy for their delivery...
Articles
Importance and uses of Vitamin B12 in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell cultures
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service