13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

90-100 μg/mL in ethanol, ≥98%

Empirical Formula (Hill Notation):
CAS Number:
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Quality Level




90-100 μg/mL in ethanol

storage temp.


SMILES string




InChI key


Biochem/physiol Actions

Expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13(S)-HODE, are decreased in human colorectal and esophageal cancers. Certain non-steroidal anti-inflammatory drugs (NSAIDs) can induce apoptosis in human colon cancer cells by increased expression of 15-LOX-1, which down-regulates PPAR-delta through 13-HODE.
PPARγ agonist


Packaged under Argon.


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Hazard Statements

Precautionary Statements


UN1170 - class 3 - PG 2 - Ethanol

WGK Germany


Flash Point(F)

57.2 °F

Flash Point(C)

14 °C

Certificate of Analysis

Certificate of Origin

Claus Schneider et al.
Cancer metastasis reviews, 30(3-4), 277-294 (2011-10-18)
Cancer initiation and progression are multistep events that require cell proliferation, migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and ultimately secondary growth. Tumor cell functions at both primary or secondary sites are controlled by...
Anna Z Pollack et al.
American journal of epidemiology, 175(7), 645-652 (2012-02-04)
Exposures to cadmium, lead, and mercury are associated with adverse health effects, including cardiovascular disease, which may be promoted by lipid peroxidation. The authors examined cadmium, lead, and mercury in relation to plasma levels of F(2)-8α isoprostanes (isoprostane), 9-hydroperoxy-10,12-octadecadienoic acid...
Wei Liu et al.
Chemical research in toxicology, 23(5), 986-995 (2010-04-29)
The primary products from peroxidation of linoleate in biological tissues and fluids are the hydroperoxy octadecadienoates, and the products normally assayed, after reduction of the hydroperoxides, are the corresponding hydroxy octadecadienoates (HODEs). The HODEs are found in tissues and fluids...
Ulaganathan Mabalirajan et al.
Journal of applied physiology (Bethesda, Md. : 1985), 107(4), 1285-1292 (2009-07-25)
We showed recently that IL-4 causes mitochondrial dysfunction in allergic asthma. IL-4 is also known to induce 12/15-lipoxygenase (12/15-LOX), a potent candidate molecule in asthma. Because vitamin E (Vit-E) reduces IL-4 and inhibits 12/15-LOX in vitro, here we tested the...
Igor Ivanov et al.
Proteins, 80(3), 703-712 (2011-12-23)
Mammalian lipoxygenases (LOXs) have been implicated in cellular defense response and are important for physiological homeostasis. Since their discovery, LOXs have been believed to function as monomeric enzymes that exhibit allosteric properties. In aqueous solutions, the rabbit 12/15-LOX is mainly...

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