H9149

Sigma-Aldrich

α-Hydroxyalprazolam

powder, ≥98% (TLC)

Empirical Formula (Hill Notation):
C17H13ClN4O
CAS Number:
Molecular Weight:
324.76
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (TLC)

form

powder

drug control

Home Office Schedule 4.1; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to off-white

solubility

methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow

SMILES string

OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12

InChI

1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2

InChI key

ZURUZYHEEMDQBU-UHFFFAOYSA-N

Packaging

25 mg in glass bottle

Caution

store dessicated and protected from light

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
R B Smith et al.
Psychopharmacology, 93(1), 105-112 (1987-01-01)
The relationships between alprazolam and metabolite concentrations and CNS effects were determined in a double-blind placebo controlled four-way crossover trial in 16 normal male volunteers. Active drug treatments consisted of 4-day regimens of 4 mg alprazolam PO daily as 2...
A J Jenkins et al.
Journal of analytical toxicology, 21(3), 218-220 (1997-05-01)
Alprazolam is one of the most widely prescribed benzodiazepines in the United States. It is generally considered a safe and effective drug for the treatment of anxiety disorders and panic attacks. Few overdoses that are due to the sole ingestion...
Annika Allqvist et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 814(1), 127-131 (2004-12-21)
A sensitive and specific method was developed for quantification of alprazolam and its two metabolites 4-hydroxyalprazolam and alpha-hydroxyalprazolam in plasma. The work up procedure was solid phase extraction. Liquid chromatography-mass spectrometry (LC-MS) was used for separation, detection and quantification of...
Alprazolam, alpha-hydroxy- and 4-hydroxyalprazolam analysis in plasma by high-performance liquid chromatography.
R L Miller et al.
Journal of chromatography, 430(1), 180-186 (1988-08-19)
Einosuke Tanaka et al.
Journal of forensic and legal medicine, 14(6), 348-351 (2007-07-17)
Alprazolam is widely used as a short-acting antidepressant and anxiolytic agent and its effect appears at very low doses while ethanol is used as a social drug worldwide. Sometimes, toxic interactions occur following combined administration of these two drugs. In...

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