H9291
Hemopexin from human plasma
≥95% (SDS-PAGE), lyophilized powder
Synonym(s):
HPX, HX, Hpxn, beta-1B-glycoprotein
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This Item | F0287 | F3879 | L8292 |
|---|---|---|---|
| technique(s) microbiological culture: suitable | technique(s) cell culture | mammalian: suitable | technique(s) ELISA: suitable | technique(s) cell culture | stem cell: suitable |
| biological source human plasma | biological source human plasma | biological source human plasma | biological source human plasma |
| assay ≥95% (SDS-PAGE) | assay >90% (SDS-PAGE) | assay - | assay - |
| mol wt ~57 kDa | mol wt 70 kDa | mol wt α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa | mol wt - |
| form lyophilized powder | form lyophilized powder | form powder | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
General description
Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein.[1]
Application
Biochem/physiol Actions
Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol.
Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.
Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.
Physical form
Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Tirthartha Chattopadhyay et al.
Biochemical and biophysical research communications, 420(4), 862-868 (2012-04-03)
Proteins containing hemopexin fold domain are suggested to have diverse functions in various living organisms. In order to investigate the structure and function of this type of protein in rice plant (Oryza sativa), the gene encoding a hemopexin fold protein
Paolo Ascenzi et al.
Biochemical and biophysical research communications, 428(2), 239-244 (2012-10-17)
Hemopexin (HPX) displays a pivotal role in heme scavenging and delivery to the liver. In turn, heme-Fe-hemopexin (HPX-heme-Fe) displays heme-based spectroscopic and reactivity properties. Here, kinetics and thermodynamics of cyanide binding to ferric and ferrous hexa-coordinate human plasma HPX-heme-Fe (HHPX-heme-Fe(III)
Laura Vicente-Vicente et al.
Toxicology, 304, 83-91 (2012-12-25)
Drug nephrotoxicity is a serious health and economic problem worldwide. Rats can be acutely sensitized to acute kidney injury (AKI) by subnephrotoxic treatments with potentially nephrotoxic drugs. Acquired sensitization to AKI poses a silent risk impossible to diagnose pre-emptively with
Hemopexin alleviates cognitive dysfunction after focal cerebral ischemia-reperfusion injury in rats
Dong B, et al.
BMC anesthesiology, 19(1), 13-13 (2019)
Kazuhiko Kawasaki et al.
European journal of oral sciences, 119 Suppl 1, 247-253 (2012-01-25)
Dental enamel is a hypermineralized tissue, containing only trace amounts of organic components. During enamel formation, matrix metalloproteinase 20 (MMP20) processes proteins comprising enamel matrix and facilitates hypermineralization. In the human genome, 24 distinct MMP genes have been identified. Among
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