H9633

L-Homocysteic acid

≥95%

• Synonym(s): L-2-Amino-4-sulfobutyric acid
• Empirical Formula (Hill Notation): C₄H₉NO₅S
• CAS Number: 14857-77-3
• Molecular Weight: 183.18
• MDL number: MFCD00066018
• PubChem Substance ID: 24895863
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥95%; ≥98% (TLC)
• form: powder
• color: white to off-white
• application(s): cell analysis
• SMILES string: N[C@@H](CCS(O)(=O)=O)C(O)=O
• InChI: 1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
• InChI key: VBOQYPQEPHKASR-VKHMYHEASA-N

Description

Application

L-Homocysteic acid has been used to study hydrogen peroxide-mediated changes in physiological and pathological conditions in the nervous system.

Biochem/physiol Actions

L-Homocysteic acid (L-HCA) is an endogenous neurotransmitter ligand of NMDA (N-methyl-D-aspartate) receptors. It is an analog of glutamate and competitively suppresses glutamate-cystine (xc^-) antiporter function in neurons, causing decrease in cysteine uptake.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves