Anti-DDX3X antibody produced in rabbit

enhanced validation

Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Anti-DEAD box protein 3, Y-chromosomal antibody produced in rabbit, Anti-ATP-dependent RNA helicase DDX3Y antibody produced in rabbit
Human Protein Atlas Number:

biological source


Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies



product line

Prestige Antibodies® Powered by Atlas Antibodies


buffered aqueous glycerol solution

species reactivity

human, rat, mouse


antibody small pack of 25 μL

enhanced validation

Learn more about Antibody Enhanced Validation


immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence




UniProt accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... DDX3X(1654)

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ATP-dependent RNA helicase DDX3Y recombinant protein epitope signature tag (PrEST)

Biochem/physiol Actions

DDX3 (DEAD box helicase 3, X-linked) is a nucleo-cytoplasmic shuttling protein belonging to the DEAD box RNA helicases family. It localizes in the nuclear membrane pores. It has been accounted for that DDX3 can hinder the colony formation of various tumor cells by decreasing cell growth rate. DDX3 has tumor suppression properties, including growth-suppressive property and transcriptional activation. It also exhibits the RNA-unwinding and adenosine triphosphatase (ATPase) activities.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.


Corresponding Antigen APREST74302.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Marisa Kamelgarn et al.
Biochimica et biophysica acta, 1862(10), 2004-2014 (2016-07-28)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Mutations in the Fused in Sarcoma/Translocated in Liposarcoma (FUS/TLS) gene cause a subset of familial ALS cases and are also implicated in sporadic ALS. FUS is typically localized to the nucleus....
Chi-Hong Chao et al.
Cancer research, 66(13), 6579-6588 (2006-07-05)
DDX3 is a DEAD box RNA helicase with diverse biological functions. Using colony formation assay, our results revealed that DDX3 inhibited the colony formation ability of various tumor cells, and this inhibition might be due to a reduced growth rate...
Venkat S R K Yedavalli et al.
Cell, 119(3), 381-392 (2004-10-28)
A single transcript in its unspliced and spliced forms directs the synthesis of all HIV-1 proteins. Although nuclear export of intron-containing cellular transcripts is restricted in mammalian cells, HIV-1 has evolved the viral Rev protein to overcome this restriction for...
Chia-Yi Su et al.
Oncotarget, 6(21), 18602-18612 (2015-06-19)
Conflicting results regarding the role of DEAD-box polypeptide 3 (DDX3) are seen not only between cancer types but also within the same type of cancer. In this study, we aimed at clarifying the prognostic significance of DDX3 in patients of...
Raffaella Franca et al.
Proteins, 67(4), 1128-1137 (2007-03-16)
Human DDX3 (hDDX3) is a DEAD-box protein shown to possess RNA-unwinding and adenosine triphosphatase (ATPase) activities. The hDDX3 protein has been implicated in nuclear mRNA export, cell growth control, and cancer progression. In addition, a role of this protein in...

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