Kuo-Liang Su et al.
The Journal of biological chemistry, 284(39), 26768-26777 (2009-07-29)
Ornithine decarboxylase (ODC) is the first enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescine. ODC is a dimeric enzyme, whereas antizyme inhibitor (AZI), a positive regulator of ODC that is homologous to ODC, exists...
Ramesh M Ray et al.
Amino acids, 46(9), 2231-2239 (2014-06-16)
Since antizyme (AZ) is known to inhibit cell proliferation and to increase apoptosis, the question arises as to whether these effects occur independently of polyamines. Intestinal epithelial cells (IEC-6) were grown in control medium and medium containing 5 mM difluoromethylornithine...
Bingping Wu et al.
Acta haematologica, 131(3), 141-147 (2013-11-07)
Ornithine decarboxylase antizyme (OAZ) has recently emerged as a potential therapeutic target in various malignant tumors because it plays vital roles in cellular functions including proliferation, differentiation, apoptosis and genomic stability. Therefore, there is a significant interest in discovering its...
Y Tosaka et al.
Genes to cells : devoted to molecular & cellular mechanisms, 5(4), 265-276 (2000-05-03)
Polyamines are known to play important roles in the proliferation and differentiation of many types of cells. However, in the testis, where polyamines such as spermidine and spermine exist in high concentrations, their roles still remains to be elucidated. We...
Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization.
S Matsufuji et al.
Genomics, 38(1), 102-104 (1996-11-15)