Molecular Profile of Human Serine
Palmitoyltransferase-1 Proximate of
Chromosome 9 Disease Susceptibility Gene Cluster in Inflammatory Cancer Cell Lines
Journal of Cancer Therapy, 5, 885-901 (2014)
Bum Chun Suh et al.
Molecular medicine reports, 9(2), 481-486 (2013-11-20)
Hereditary sensory and autonomic neuropathy type I (HSAN I) is an autosomal dominant disease characterized by prominent sensory impairment, resulting in foot ulcers or amputations and has a juvenile to adult onset. The major underlying causes of HSAN I are...
Simon J Myers et al.
DNA and cell biology, 33(7), 399-407 (2014-03-29)
Mutations in serine palmitoyltransferase long chain subunit 1 (SPTLC1) cause the typical length-dependent axonal degeneration hereditary sensory neuropathy type 1 (HSN1). Transmission electron microscopy studies on SPTLC1 mutant lymphoblasts derived from patients revealed specific structural abnormalities of mitochondria. Swollen mitochondria...
Gongshe Han et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(20), 8186-8191 (2009-05-07)
Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In yeast, SPT is composed of a heterodimer of 2 highly-related subunits, Lcb1p and Lcb2p, and a third subunit, Tsc3p, which increases enzyme activity markedly and is required for...
Jia Wei et al.
Biochimica et biophysica acta, 1791(8), 746-756 (2009-04-14)
Serine palmitoyltransferase (SPT) has been localized to the endoplasmic reticulum (ER) by subcellular fractionation and enzymatic assays, and fluorescence microscopy of epitope-tagged SPT; however, our studies have suggested that SPT subunit 1 might be present also in focal adhesions and...